- Basic information
- CohesinDB ID: CDBP00420879
- Locus: chr21-44043223-44044061
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Data sourse: ENCSR000BLD, GSE143937, GSE67783, ENCSR000BKV, GSE72082, GSE86191, ENCSR000EGW, ENCSR000BLS, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, ENCSR153HNT, ENCSR703TNG, GSE25021
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Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, Hep-G2, K-562, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SMC3,Rad21,SA2,SA1
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
62% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 78%,
"4_Tx": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, SOX2, XBP1, FOXA1, LEO1, HDGF, ATF3, ZNF362, PRDM1, PAX5, TRIM28, RBM39, SAP30, ESR1, CTCF, TCF12, E4F1, DPF2, E2F6, SOX6, TEAD4, EED, CHD8, ZSCAN5D, RUNX1T1, CTBP1, MTA2, DUX4, ZBTB48, STAT1, NBN, ZNF300, ERG, PBX1, MYC, SMARCA4, RAD21, GRHL3, GABPA, IKZF1, RCOR1, NR3C1, KMT2A, EZH2, SPI1, HDAC2, ZNF182, FLI1, SMARCA5, ZIM3, SMC1A, ZFX, SMAD3, TRIM22, ZBTB2, ZNF384, NOTCH1, CDK6, GATA4, ETV6, SUPT5H, CDK8, FOS, MED1, MYB, ZNF3, ZNF22, RBM22, BCL11A, NKX2-5, REST, TCF3, MLLT1, PPARG, TBL1X, MTA3, EBF1, ZNF600, ZSCAN16, WT1, ZKSCAN1, YY1, RELA, NEUROD1, SP140, ZIC2, HIF1A, MAX, ZNF143, GATA1, PLAG1, NCOA3, KDM5B, TP53, PHOX2B, HSF1, RNF2, MYNN, BRD4, ILF3, JUND, MAZ, ZZZ3
- Target gene symbol (double-evidenced CRMs): PFKL,CFAP410,PKNOX1,AGPAT3,LRRC3,TRAPPC10,DNMT3L
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000160199,
ENSG00000160216,
ENSG00000160218,
ENSG00000142182,
ENSG00000141959,
ENSG00000160226,
ENSG00000160233,
- Related loop:
chr21:43000000-43025000~~chr21:44025000-44050000,
chr21:43175000-43200000~~chr21:44025000-44050000,
chr21:43200000-43225000~~chr21:44025000-44050000,
chr21:43350000-43375000~~chr21:44025000-44050000,
chr21:43925000-43950000~~chr21:44025000-44050000,
chr21:44025000-44050000~~chr21:44250000-44275000,
chr21:44025000-44050000~~chr21:44275000-44300000,
chr21:44025000-44050000~~chr21:44300000-44325000,
chr21:44025000-44050000~~chr21:44450000-44475000,
chr21:5125000-5150000~~chr21:44025000-44050000,