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Basic information

CohesinDB ID: CDBP00420883

Locus: chr21-44049059-44050644

Data sourse: ENCSR000BTQ, GSE67783, GSE72082, GSE86191, ENCSR000BLY, GSE206145, ENCSR153HNT, ENCSR703TNG

Cell type: MCF-7, RPE, HCT-116, SK-N-SH, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 50%, "4_Tx": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: POU2F2, CHD8, PPARG, BCL6, ZNF263, MYCN, CRY1, ZFX, ZNF600, XBP1, ZSCAN16, WT1, ZBTB48, ZNF534, FOXA1, DUX4, ERG3, LEO1, ERG, YY1, RELA, CREBBP, ASCL1, RUNX2, MYC, SMARCA4, RAD21, SP140, ZIC2, HIF1A, ARNT, GABPA, STAT3, MAX, TAL1, ZNF143, CDK8, SUPT5H, DNMT3B, AGO2, CEBPB, PDX1, NCOA3, ZNF573, ESR1, ZNF334, ZNF652, MYOD1, EBF3, PHOX2B, CTCF, RBM22, JUN, BAF155, BCL11A, MNT, AR, SSRP1, GATA2, REST, IRF4, HSF1, ILF3, CLOCK, E2F1, MAZ, STAG1, EED

Target gene symbol (double-evidenced CRMs): PKNOX1,AGPAT3,CFAP410,RRP1,PTTG1IP,TRPM2,PFKL,TRAPPC10,UBE2G2,SUMO3,LRRC3,DNMT3L,TSPEAR,GATD3A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000160221, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255,

eachgene

Deatailed information for cohesin site CDBP00420883