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Basic information

CohesinDB ID: CDBP00420888

Locus: chr21-44062415-44062878

Data sourse: GSE206145-NatGen2015, GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 64%, "5_TxWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NME2, XBP1, FOXA1, LEO1, PBX2, ZFHX2, TFAP4, HDGF, ATF3, HNRNPUL1, ATF4, MECOM, PAX5, MAF, JMJD1C, ELF1, TRIM28, BCLAF1, LMO2, ESR1, OCA2, MLL, CTCF, TCF12, JUN, BAF155, ARID5B, LMO1, TFAP2C, RBPJ, GLIS1, POU2F2, CHD8, MYCN, POU5F1, ZNF263, RUNX1T1, CDK7, ZBTB48, ZSCAN5A, DUX4, ERG2, SP4, ERG, PBX1, ZNF341, MYC, RAD21, FOXP2, GRHL3, GABPA, STAT3, PRDM14, IKZF1, NFE2, DNMT3B, ZNF750, NR3C1, CEBPB, STAT5B, KMT2A, CREB1, EZH2, BMPR1A, SPI1, GATA2, MXD3, FLI1, NCOA2, RUNX1, SMC1A, MAFG, BCL6, CEBPA, ZFX, SMAD3, TET2, ERG3, PRPF4, NOTCH1, RUNX2, ARNT, NRF1, SUPT5H, CHD1, CDK8, TEAD3, TERF1, CEBPD, MYB, ZNF3, C11orf30, EVI1, STAT5A, RBM22, SP1, BCL11A, NR4A1, BCOR, TCF3, STAG1, MLLT1, SKI, TRP47, FOXA2, AGO1, CREM, MEIS1, PAF1, ZNF600, GTF2B, WT1, ESR2, ZBTB33, MEF2C, KDM1A, ZNF19, RELA, NEUROD1, SP140, TCF4, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, AGO2, GATA1, CEBPG, BCL11B, NCOA3, MED, ZNF334, EGR2, TBX21, AR, TAF1, EGR1, HSF1, NCOR1, JUND, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): SUMO3,AGPAT3,TRPM2,PKNOX1,RRP1,PFKL,TSPEAR,TRAPPC10,DNMT3L,PTTG1IP,GATD3A,CFAP410,LRRC3,UBE2G2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 1

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000160221, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255,

eachgene

Deatailed information for cohesin site CDBP00420888