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Basic information

CohesinDB ID: CDBP00420892

Locus: chr21-44067082-44068169

Data sourse: ENCSR000BLD, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000EGW, GSE105028, GSE25021, GSE131606, ENCSR000EDW, ENCSR000BUC, ENCSR917QNE, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, ENCSR000EEG, ENCSR879KXD, ENCSR000BLS, ENCSR000ECE, ENCSR000BTQ, ENCSR167MTG, ENCSR054FKH, ENCSR153HNT

Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, Hep-G2, A-549, DKO, K-562, Liver, HSPC, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 43%, "4_Tx": 43%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, MEIS2, XBP1, FOXA1, HLF, PBX2, ZFHX2, TFAP4, HDGF, SMARCE1, ETV1, ESR1, OCA2, CTCF, BAF155, ZNF423, E2F1, EHMT2, TFAP2C, MYCN, ZNF263, ID3, CTBP1, ZBTB48, NBN, ERG2, ERG, MYC, DNMT1, RAD21, XRCC5, IKZF1, RCOR1, DNMT3B, NR2F6, CREB1, PHF8, HDAC2, GATA2, NFIL3, NCOA2, ATF1, ETV5, RUNX1, CBX1, SMC1A, HDAC1, SIN3A, ZFX, TET2, ERG3, NFXL1, ZBTB2, CREBBP, BRD9, ARNT, TFDP1, SUPT5H, TEAD3, PIAS1, NCOA1, RBM22, BCL11A, ARID2, REST, ZNF479, AFF1, SMC3, STAG1, FOXA2, MTA3, CREM, E2F8, WT1, YY1, RELA, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, ZNF740, NRIP1, ZNF143, TLE3, NCOA3, NR2F2, GFI1B, NR2F1, KDM5B, EGR2, ARID4B, AR, EGR1, RB1, ZBTB26, NCOR1, HSF1, BRD4, JUND, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): TRAPPC10,AGPAT3,UBE2G2,LRRC3,GATD3A,SUMO3,RRP1,TSPEAR,TRPM2,CFAP410,DNMT3L,PKNOX1,PFKL,PTTG1IP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 7

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000160221, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255,

eachgene

Deatailed information for cohesin site CDBP00420892