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Basic information

CohesinDB ID: CDBP00420895

Locus: chr21-44071581-44073072

Data sourse: ENCSR000BLD, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE110061, GSE129526, GSE111913, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, GSE50893, GSE206145, ENCSR153HNT, GSE130135, ENCSR703TNG, GSE25021, GSE108869

Cell type: MCF-7, GM2630, H1-hESC, Fibroblast, HCT-116, RPE, HEK293T, SNYDER, HeLa-S3, RT-112, K-562, HSPC, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 49%, "5_TxWk": 47%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, POU2F2, CHD8, BRD1, FOXA2, MYCN, POU5F1, TBL1X, TOP2A, ZFX, ZNF600, WT1, ZBTB48, TET2, ERG3, ZBTB33, DDX5, ERG2, LEO1, ZFHX2, ERG, YY1, RELA, ZBTB2, OGG1, MYC, EZH1, RAD21, SP140, ARNT, GRHL3, CBFB, MORC2, STAT3, MAX, SUPT5H, AGO2, DNMT3B, TEAD1, SCRT2, ZNF3, ESR1, NFKB1, EGR2, CTCF, RBM22, JUN, AR, RXR, REST, EGR1, BRD4, SCRT1, MAZ, AATF, STAG1, AHR

Target gene symbol (double-evidenced CRMs): AGPAT3,RRP1,PFKL,TSPEAR,UBE2G2,PKNOX1,LRRC3,GATD3A,PTTG1IP,SUMO3,DNMT3L,TRAPPC10,TRPM2,CFAP410

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000160221, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255,

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Deatailed information for cohesin site CDBP00420895