- Basic information
- CohesinDB ID: CDBP00420917
- Locus: chr21-44153124-44161484
-
Data sourse: ENCSR000BLD, GSE116868, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE165895, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE116344, GSE94872, GSE98367, ENCSR879KXD, GSE206145, GSE62063, ENCSR000BMY, GSE55407, ENCSR000BTQ, GSE38395, GSE111913, GSE155324, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, ENCSR000ECS, GSE131577
-
Cell type: MDM, RH4, GM10847, GM2610, GM19240, OCI-AML-3, HSPC, HuCC-T1, B-cell, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GM19239, RT-112, GM19193, THP-1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HL-60, HUVEC, HCAEC, GM19238, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 22% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.467
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
62% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"7_Enh": 40%,
"2_TssAFlnk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: RUNX1, NR3C1
- Target gene symbol (double-evidenced CRMs): TSPEAR,PFKL,GATD3A,DNMT3L
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 65
- Number of somatic mutations (non-coding): 52
- Related genes and loops
- Related gene:
ENSG00000160221,
ENSG00000142182,
ENSG00000141959,
ENSG00000175894,
- Related loop:
chr21:44125000-44150000~~chr21:44275000-44300000,
chr21:44125000-44150000~~chr21:44475000-44500000,
chr21:44150000-44175000~~chr21:44250000-44275000,
chr21:44150000-44175000~~chr21:44275000-44300000,
chr21:44150000-44175000~~chr21:44475000-44500000,
chr21:5075000-5100000~~chr21:44150000-44175000,
chr21:5100000-5125000~~chr21:44125000-44150000,
chr21:5100000-5125000~~chr21:44150000-44175000,