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Basic information

CohesinDB ID: CDBP00420930

Locus: chr21-44195889-44198272

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE103477, GSE111537, GSE25021, GSE93080, ENCSR000DZP, GSE67783, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE98367, GSE206145, GSE62063, ENCSR000BMY, ENCSR000BTQ, GSE38395, ENCSR153HNT, GSE50893, GSE126755

Cell type: MCF-7, GM18526, GM12892, Fibroblast, Macrophage, Monocytes, SNYDER, THP-1, GM12878, Ramos, OCI-AML-3, hLCL, K-562, Liver, Neutrophil, HSPC, GM19099, B-cell

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.800

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: False

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 23%, "5_TxWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ESR1

Target gene symbol (double-evidenced CRMs): GATD3A,TRAPPC10,PFKL,CFAP410,TSPEAR,TRPM2

Function elements

Human SNPs: Chronic_inflammatory_diseases_(ankylosing_spondylitis,_Crohn's_disease,_psoriasis,_primary_sclerosing_cholangitis,_ulcerative_colitis)_(pleiotropy)

Number of somatic mutations (coding): 13

Number of somatic mutations (non-coding): 13

Related genes and loops

Related gene: ENSG00000160218, ENSG00000160221, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

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Deatailed information for cohesin site CDBP00420930