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Basic information

CohesinDB ID: CDBP00420960

Locus: chr21-44253503-44259739

Data sourse: GSE118494, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE138405, GSE132649, GSE116868, GSE105028, GSE101921, GSE206145-NatGen2015, GSE50893, GSE206145, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE108869, GSE94872, ENCSR000ECS

Cell type: MCF-7, RPE, T-47D, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, MB157, HUVEC, HCAEC, GM12890, HeLa-S3, IMR-90, K-562, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.811

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 33%, "15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, SOX2, XBP1, FOXA1, SUZ12, RBFOX2, UBTF, ZFHX2, TFAP4, ATF3, ZNF362, ZNF444, CBFB, MECOM, TP63, ZNF506, TEAD1, ZNF121, ESR1, OCA2, MED26, CTCF, JUN, BAF155, KLF1, EP300, IRF4, RFX5, E2F1, ZNF528, SMC1, TFAP2C, EED, GLIS1, POU2F2, CHD8, ZSCAN5D, MYCN, POU5F1, RUNX1T1, KDM4C, ZNF263, CTBP1, ZBTB17, ZBTB48, ZSCAN5A, DDX5, SAP130, ERG2, ERG, OGG1, ETS1, MYC, RAD21, GRHL3, STAT3, PRDM14, IKZF1, RCOR1, DNMT3B, VDR, ZNF750, NR3C1, SRSF3, CEBPB, HNRNPL, CREB1, EZH2, GRHL2, GABPB1, ZHX2, SPI1, KLF17, HDAC2, GATA2, FLI1, MXI1, HCFC1R1, NFIL3, ATF1, RUNX1, BCL6, CEBPA, SIRT6, CRY1, ZFX, SMAD3, TET2, ERG3, SMARCC1, RARA, ZNF384, CREBBP, RUNX2, GATA4, PBX4, ARNT, SOX11, ZNF48, NCAPH2, FOS, SMARCB1, MED1, TEAD3, KDM6B, L3MBTL2, RBM22, MAFK, ARID2, REST, ZBTB7A, ZHX1, TCF3, AATF, SMC3, STAG1, TRP47, CBFA2T2, PPARG, AGO1, FOXA2, MTA3, CHD2, NFATC1, CREM, ZNF600, TBL1X, WT1, ZNF30, MAFF, ZNF662, YY1, RELA, JUNB, BRG1, SP140, ZIC2, HIF1A, ZFP36, OTX2, TAL1, MAX, NRIP1, ZNF143, AGO2, KLF4, SP7, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, EGR2, AR, RXR, HEXIM1, HSF1, RNF2, ZBTB26, BRD4, JUND, NCOR1, MAZ, BRCA1, AHR

Target gene symbol (double-evidenced CRMs): WDR4,DNMT3L,TSPEAR,PDXK,AGPAT3,PCBP3,TRAPPC10,CSTB,NDUFV3,ADARB1,PKNOX1,RRP1B,GATD3A,SLC37A1,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 334

Number of somatic mutations (non-coding): 76

Related genes and loops

Related gene: ENSG00000160179, ENSG00000160190, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160216, ENSG00000160218, ENSG00000160221, ENSG00000142182, ENSG00000175894, ENSG00000197381, ENSG00000183570,

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Deatailed information for cohesin site CDBP00420960