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Basic information

CohesinDB ID: CDBP00420961

Locus: chr21-44260974-44262029

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 43%, "14_ReprPCWk": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, SOX2, PATZ1, SUZ12, RXRB, ZFHX2, TFAP4, HNRNPK, ZNF90, ATF3, ZFP64, THAP1, ZNF362, CHD7, PRDM1, CBFB, ZNF189, TP63, KLF5, ELF1, RBM39, ESR1, OCA2, USF2, CTCF, KLF1, ZBTB20, SOX5, TRIM24, GTF2F1, GATAD2A, TFAP2C, EED, GLIS1, POU2F2, NANOG, CHD8, ZSCAN5D, POU5F1, MYCN, ZNF263, CTBP1, ZBTB48, ZSCAN5A, SAP130, DDX5, ERG2, SP4, ERG, ASCL1, OGG1, ZNF341, MYC, SMARCA4, GRHL3, GABPA, PRDM14, IKZF1, DNMT3B, NR2F6, KMT2A, KLF8, GRHL2, GABPB1, ZHX2, KLF17, PCBP1, MXD3, PTBP1, RUNX1, SIRT6, ZFX, ZNF534, SMAD3, PCBP2, ZNF770, ERG3, TET2, SMARCC1, PRDM10, RARA, ZNF384, SMAD2, ARNT, ZBTB10, ZNF48, SMAD4, NCAPH2, SP2, FOS, CDK8, SMARCB1, TEAD3, VEZF1, ZNF3, KLF9, USF1, BCL11A, SP1, TFAP2A, HNF4A, ZBTB7A, GLIS2, TCF3, FOXP1, AATF, SMC3, STAG1, TRP47, CBFA2T2, AGO1, FOXA2, CREM, SS18, ZNF600, GTF2B, WT1, YY1, RELA, TARDBP, NEUROD1, BRG1, SP140, ZIC2, HIF1A, PCGF1, OTX2, MAF1, MAX, GATA1, AGO2, CBX2, PLAG1, KLF4, NR2F1, KDM5B, EGR2, T, AR, EGR1, RB1, HEXIM1, HSF1, TFIIIC, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): TSPEAR,PDXK,SLC37A1,AGPAT3,WDR4,RRP1B,ABCG1,GATD3A,PCBP3,PKNOX1,CSTB,ADARB1,TRAPPC10,NDUFV3,DNMT3L

Function elements

Human SNPs: .

Number of somatic mutations (coding): 55

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000160179, ENSG00000160190, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160216, ENSG00000160218, ENSG00000160221, ENSG00000142182, ENSG00000175894, ENSG00000197381, ENSG00000183570,

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Deatailed information for cohesin site CDBP00420961