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Basic information

CohesinDB ID: CDBP00420962

Locus: chr21-44262549-44268928

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE165895, GSE138405, GSE67783, GSE86191, GSE76893, GSE101921, GSE51234, GSE206145-NatGen2015, GSE120943, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE93080, GSE94872, ENCSR000EEG, ENCSR338DUC, GSE76815, GSE98367, ENCSR193NSH, GSE168045, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR748MVX, ENCSR984DZW, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, GSE38411, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, SC, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 48% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.322

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 37%, "14_ReprPCWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, SOX2, PATZ1, SUZ12, RXRB, ZFHX2, TFAP4, HNRNPK, ZNF90, ATF3, ZFP64, THAP1, ZNF362, CHD7, PRDM1, CBFB, ZNF189, TP63, KLF5, ELF1, RBM39, ESR1, OCA2, USF2, CTCF, KLF1, ZBTB20, SOX5, TRIM24, GTF2F1, GATAD2A, TFAP2C, EED, GLIS1, POU2F2, NANOG, CHD8, ZSCAN5D, POU5F1, MYCN, ZNF263, CTBP1, ZBTB48, ZSCAN5A, SAP130, DDX5, ERG2, SP4, ERG, ASCL1, OGG1, ZNF341, MYC, SMARCA4, GRHL3, GABPA, PRDM14, IKZF1, DNMT3B, NR2F6, KMT2A, KLF8, GRHL2, GABPB1, ZHX2, KLF17, PCBP1, MXD3, PTBP1, RUNX1, SIRT6, ZFX, ZNF534, SMAD3, PCBP2, ZNF770, ERG3, TET2, SMARCC1, PRDM10, RARA, ZNF384, SMAD2, ARNT, ZBTB10, ZNF48, SMAD4, NCAPH2, SP2, FOS, CDK8, SMARCB1, TEAD3, VEZF1, ZNF3, KLF9, USF1, BCL11A, SP1, TFAP2A, HNF4A, ZBTB7A, GLIS2, TCF3, FOXP1, AATF, SMC3, STAG1, TRP47, CBFA2T2, AGO1, FOXA2, CREM, SS18, ZNF600, GTF2B, WT1, YY1, RELA, TARDBP, NEUROD1, BRG1, SP140, ZIC2, HIF1A, PCGF1, OTX2, MAF1, MAX, GATA1, AGO2, CBX2, PLAG1, KLF4, NR2F1, KDM5B, EGR2, T, AR, EGR1, RB1, HEXIM1, HSF1, TFIIIC, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): GATD3A,TRAPPC10,CSTB,TSPEAR,DNMT3L,NDUFV3,ABCG1,WDR4,AGPAT3,PDXK,RRP1B,PKNOX1,ADARB1,PCBP3,SLC37A1

Function elements

Human SNPs: Dental_caries_(decayed,_missing_and_filled_teeth)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 25

Related genes and loops

Related gene: ENSG00000160179, ENSG00000160190, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160216, ENSG00000160218, ENSG00000160221, ENSG00000142182, ENSG00000175894, ENSG00000197381, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00420962