- Basic information
- CohesinDB ID: CDBP00420963
- Locus: chr21-44270131-44273478
-
Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT
-
Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SA2
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
74% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 48%,
"14_ReprPCWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, XBP1, FOXA1, ATF3, THAP1, CBFB, TP63, ZNF736, ELF1, TEAD1, SNAI2, ESR1, OCA2, USF2, CTCF, JUN, PAX8, E2F6, E2F4, ZNF528, GTF2F1, TFAP2C, EED, POU2F2, BRD1, MYCN, POU5F1, RUNX1T1, ZNF263, ZNF317, ZBTB48, ZSCAN5A, ERG2, ERG, ASCL1, OGG1, ETS1, MYC, SMARCA4, GRHL3, STAT3, XRCC5, IKZF1, DNMT3B, HNRNPH1, NR3C1, EZH2, SPI1, KLF17, PCBP1, GATAD2B, MXD3, ZGPAT, RUNX1, SMC1A, CRY1, SIN3A, ZFX, TET2, ERG3, CBX8, ZNF384, TAF15, ARNT, ZNF48, SMARCB1, CDK8, CHD1, MED1, TEAD3, TERF1, ZNF3, KLF9, NCOA1, SETDB1, BCL11A, HNRNPLL, AATF, SMC3, STAG1, NFATC3, TRP47, CBFA2T2, PPARG, FOXA2, ZNF316, EBF1, ZNF600, WT1, YY1, RELA, BRG1, MCM3, SP140, ZIC2, HIF1A, MAX, NRIP1, ZNF143, CBX2, PLAG1, KDM5B, NFKB1, EGR2, KAT8, AR, RXR, HEXIM1, HSF1, ZBTB26, RNF2, BRD4, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): GATD3A,ABCG1,CSTB,NDUFV3,SLC37A1,ADARB1,PKNOX1,WDR4,AGPAT3,PDXK,PCBP3,TSPEAR,TRAPPC10,RRP1B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 14
- Related genes and loops
- Related gene:
ENSG00000160179,
ENSG00000160190,
ENSG00000160193,
ENSG00000160194,
ENSG00000160199,
ENSG00000160208,
ENSG00000160209,
ENSG00000160213,
ENSG00000160216,
ENSG00000160218,
ENSG00000160221,
ENSG00000175894,
ENSG00000197381,
ENSG00000183570,
- Related loop:
chr21:27500000-27525000~~chr21:44275000-44300000,
chr21:42050000-42075000~~chr21:44250000-44275000,
chr21:42225000-42250000~~chr21:44250000-44275000,
chr21:42525000-42550000~~chr21:44250000-44275000,
chr21:42875000-42900000~~chr21:44250000-44275000,
chr21:42975000-43000000~~chr21:44250000-44275000,
chr21:43175000-43200000~~chr21:44275000-44300000,
chr21:43200000-43225000~~chr21:44250000-44275000,
chr21:43275000-43300000~~chr21:44250000-44275000,
chr21:43275000-43300000~~chr21:44275000-44300000,
chr21:43300000-43325000~~chr21:44250000-44275000,
chr21:43300000-43325000~~chr21:44275000-44300000,
chr21:43325000-43350000~~chr21:44275000-44300000,
chr21:43350000-43375000~~chr21:44250000-44275000,
chr21:43350000-43375000~~chr21:44275000-44300000,
chr21:43675000-43700000~~chr21:44250000-44275000,
chr21:43750000-43775000~~chr21:44250000-44275000,
chr21:43775000-43800000~~chr21:44275000-44300000,
chr21:43800000-43825000~~chr21:44275000-44300000,
chr21:43825000-43850000~~chr21:44250000-44275000,
chr21:43825000-43850000~~chr21:44275000-44300000,
chr21:43850000-43875000~~chr21:44250000-44275000,
chr21:43875000-43900000~~chr21:44250000-44275000,
chr21:43900000-43925000~~chr21:44250000-44275000,
chr21:43950000-43975000~~chr21:44250000-44275000,
chr21:43950000-43975000~~chr21:44275000-44300000,
chr21:43975000-44000000~~chr21:44250000-44275000,
chr21:43975000-44000000~~chr21:44275000-44300000,
chr21:43979276-43980550~~chr21:44266775-44268941,
chr21:44000000-44025000~~chr21:44250000-44275000,
chr21:44000000-44025000~~chr21:44275000-44300000,
chr21:44025000-44050000~~chr21:44250000-44275000,
chr21:44025000-44050000~~chr21:44275000-44300000,
chr21:44050000-44075000~~chr21:44250000-44275000,
chr21:44050000-44075000~~chr21:44275000-44300000,
chr21:44075000-44100000~~chr21:44250000-44275000,
chr21:44075000-44100000~~chr21:44275000-44300000,
chr21:44125000-44150000~~chr21:44275000-44300000,
chr21:44150000-44175000~~chr21:44250000-44275000,
chr21:44150000-44175000~~chr21:44275000-44300000,
chr21:44175000-44200000~~chr21:44275000-44300000,
chr21:44250000-44275000~~chr21:44475000-44500000,
chr21:44250000-44275000~~chr21:44675000-44700000,
chr21:44250000-44275000~~chr21:45125000-45150000,
chr21:44250000-44275000~~chr21:45900000-45925000,
chr21:5025000-5050000~~chr21:44250000-44275000,
chr21:5025000-5050000~~chr21:44275000-44300000,
chr21:5050000-5075000~~chr21:44250000-44275000,
chr21:5050000-5075000~~chr21:44275000-44300000,
chr21:5100000-5125000~~chr21:44250000-44275000,
chr21:5100000-5125000~~chr21:44275000-44300000,