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Basic information

CohesinDB ID: CDBP00420969

Locus: chr21-44279636-44308260

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 86% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.100

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 22%, "2_TssAFlnk": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, XBP1, PATZ1, FOXA1, SUZ12, ZFHX2, HDGF, ATF3, RUNX3, PRDM1, PAX5, KLF5, BCLAF1, RBM39, ESR1, USF2, CTCF, TCF12, EP300, KLF1, DPF2, ZNF528, TFAP2C, EED, GLIS1, POU2F2, CHD8, MYCN, POU5F1, TOP2A, MTA2, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ERG2, SP4, HNF4G, ASCL1, ZBTB8A, MYC, EZH1, SMARCA4, GRHL3, GABPA, PRDM14, IKZF1, DNMT3B, NR3C1, SRSF3, HNRNPL, KMT2A, SPI1, KLF17, GATAD2B, MXD3, SMARCA5, RELB, HCFC1R1, RUNX1, SIRT6, ZFX, TET2, CBX8, ERG3, ZNF770, SMARCC1, ZNF384, OSR2, BACH1, PRDM9, FOS, CDK8, MED1, TEAD3, ZEB1, SCRT2, ZNF3, NCOA1, BCL11A, HNRNPLL, TCF3, AATF, SMC3, STAG1, MLLT1, NFATC3, TRP47, CBFA2T2, FOXA2, EBF1, ZNF600, GTF2B, WT1, ZNF30, HOXB13, YY1, RELA, BRG1, SP140, ZFP36, ZIC2, HIF1A, GATA3, KLF15, MAX, SPIB, ZNF143, CBX2, PLAG1, ZNF592, SP7, NEUROG2, NR2F1, KDM5B, ZNF687, ZBTB6, NFKB1, MYOD1, EGR2, PHOX2B, BHLHE40, AR, EGLN2, HEXIM1, ZBTB26, RNF2, HSF1, BRD4, SCRT1, CLOCK, MAZ, ZSCAN23, AHR

Target gene symbol (double-evidenced CRMs): UBE2G2,SUMO3,CSTB,GATD3A,RRP1,TRAPPC10,PFKL,PWP2,AGPAT3

Function elements

Human SNPs: Addison's_disease

Number of somatic mutations (coding): 691

Number of somatic mutations (non-coding): 494

Related genes and loops

Related gene: ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000241945, ENSG00000160221, ENSG00000141959, ENSG00000184787, ENSG00000184900,

eachgene

Deatailed information for cohesin site CDBP00420969