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Basic information

CohesinDB ID: CDBP00420971

Locus: chr21-44320741-44336654

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE131606, GSE25021, GSE165895, ENCSR000BTU, GSE67783, GSE86191, GSE138405, GSE206145-NatGen2015, GSE120943, GSE116344, GSE106870, GSE145327, GSE118494, ENCSR338DUC, GSE98367, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, GSE110061, GSE129526, GSE111913, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE38411

Cell type: RH4, CVB-hiPSC, GM19240, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, GM2255, IMR-90, BCBL-1, K-562, GM18486, HFFc6, DKO, H1-hESC, Monocytes, MB157, GM12891, SK-N-SH, GM19239, RT-112, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.667

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 45%, "5_TxWk": 38%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, ZNF616, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, ZNF429, MORC2, PAX5, ZNF320, SFPQ, TEAD1, SNAPC1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, ARID5B, E4F1, SOX5, PAX8, E2F4, DEK, ZNF674, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, TOP2A, BRD3, CTBP1, ZMYND11, STAT1, SAP130, ERG, PAX6, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, ZNF8, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, NR2C2, ZNF785, RELB, HCFC1R1, EP400, RUVBL2, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, PALB2, ZNF654, TET2, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, ZNF331, SMAD1, PIAS1, NR1H2, C11orf30, MBD1, STAT5A, GSPT2, IKZF5, ARID2, RBM25, ZNF605, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, SS18, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, MPHOSPH8, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, ZNF281, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, ZNF621, HNF1A, XBP1, KDM4B, ZNF101, PBX2, SRSF4, ZNF596, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, MAF, JMJD1C, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, DDX20, ZNF280A, PDX1, RBPJ, MLX, TFAP2C, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, DDX5, NBN, PBX1, ONECUT1, KDM4A, HOMEZ, FOXP2, ZNF2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, SMARCA5, NFIL3, THAP11, LDB1, SOX13, AFF4, POU4F2, ZNF513, ZMIZ1, ZNF18, CEBPZ, SP3, ARNT, NFIB, BACH1, ZNF48, PRDM9, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, TEAD3, DIDO1, ZXDB, ZNF680, U2AF1, TAF7, KLF9, ZNF41, TBX5, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, SALL4, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, KLF7, ZNF441, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, ZNF143, AGO2, MTA1, TP53, ZNF334, ZSCAN22, NFKB1, ZNF140, PHF5A, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, CUX1, ZSCAN23, TBX2, PGR, FANCL, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, ZNF524, KLF1, SOX9, ZNF260, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ASH1L, ZSCAN5A, ELK4, ERG2, HIC1, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, ZNF24, PHF21A, KLF12, NKX2-1, GABPA, MCRS1, STAT3, SOX10, IKZF1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, MRTFA, PHF8, ZNF436, SPI1, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, TAF9B, ZNF490, NFYB, ZNF554, ZNF76, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF384, NFYC, CREBBP, TAF15, ZNF169, ZNF35, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, SREBF2, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, ZNF816, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, ZNF662, TCF7, YY2, FOXO3, RELA, TARDBP, ZNF282, SKIL, MAX, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, KMT2D, ZNF324, HEXIM1, ZNF280D, DMAP1, AHR, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, SFMBT1, LYL1, ZNF90, INSM2, NFIC, ZNF362, CTCFL, KLF14, MECOM, ZNF736, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, ZNF649, MLLT3, GATAD1, GMEB2, ARID3A, USP7, ASCL1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF285, ARNTL, ZNF750, FEZF1, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, ZC3H11A, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF534, ZNF335, SMAD3, NMYC, TWIST1, NSD2, IRF2, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, ZSCAN30, NRF1, NR2C1, SUPT5H, FOS, CHD1, TGIF2, MED1, KDM6B, ZNF558, SCRT2, CEBPD, MYB, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, ZNF283, NCOA4, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, HIF1A, OTX2, ZNF519, ZNF740, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, ZNF248, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): PKNOX1,ITGB2,TRAPPC10,LRRC3,CFAP410,TSPEAR,FAM207A,ITGB2-AS1,PCBP3,RRP1B,UBE2G2,PTTG1IP,ADARB1,PFKL,SLC19A1,HSF2BP,GATD3A,SUMO3,TRPM2,COL18A1,RRP1,PDXK,SLC37A1,AGPAT3,CSTB

Function elements

Human SNPs: Hemoglobin_levels

Number of somatic mutations (coding): 764

Number of somatic mutations (non-coding): 397

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160199, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000160221, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00420971