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Basic information

CohesinDB ID: CDBP00420974

Locus: chr21-44347920-44356379

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, GSE105028, GSE103477, GSE111537, GSE131606, GSE25021, ENCSR917QNE, GSE165895, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE206145-NatGen2015, GSE120943, GSE116344, GSE145327, GSE118494, GSE98367, GSE206145, ENCSR000ECE, GSE62063, ENCSR000BMY, GSE55407, GSE111913, GSE155324, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, GSE38411

Cell type: RH4, GM2610, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HeLa-S3, IMR-90, BCBL-1, K-562, GM18486, HFFc6, DKO, H1-hESC, SNYDER, Monocytes, MB157, Lymphoblast, GM12878, RT-112, THP-1, GM19099, Macrophage, MCF-7, Ramos, HCT-116, Hep-G2, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.644

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 22%, "13_ReprPC": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, XBP1, LEO1, MLL4, ATF3, ZBTB5, MITF, MAF, TRIM28, LMO2, ESR1, USF2, JUN, CTCF, MNT, E2F6, ZNF350, TFAP2C, EED, POU2F2, CHD8, MYCN, ID3, KDM4C, ZBTB48, STAT1, ERG, MYC, RFX1, GRHL3, NKX2-1, STAT3, DNMT3B, ESRRA, EZH2, GRHL2, ZHX2, SPI1, NFYB, ETV5, CC2D1A, RUNX1, EZH2phosphoT487, SIRT6, ZFX, TET2, PRDM10, CREBBP, ZNF384, ATF2, ZNF48, NFYA, FOXM1, SP2, FOS, MYB, C11orf30, L3MBTL2, SETDB1, STAT5A, USF1, REST, ZNF479, RBM25, AATF, STAG1, NFATC3, TRP47, FOXA2, CBX3, ZSCAN16, WT1, MEF2C, HOXB13, YY1, RELA, AHR, SP140, TCF4, HIF1A, MGA, MAF1, MAX, SPIB, PLAG1, KDM5B, TP53, PKNOX1, ZNF334, NFKB1, AR, ZNF445, HEXIM1, HSF1, RNF2, BRD4, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): PDXK,ADARB1,SLC37A1,ITGB2-AS1,HSF2BP,TRAPPC10,UBE2G2,SLC19A1,ITGB2,PKNOX1,RRP1B,FAM207A,TSPEAR,PTTG1IP,GATD3A,LRRC3,SUMO3,PCBP3,CSTB,TRPM2,COL18A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 295

Number of somatic mutations (non-coding): 38

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160199, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160218, ENSG00000160221, ENSG00000142185, ENSG00000160233, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00420974