- Basic information
- CohesinDB ID: CDBP00420975
- Locus: chr21-44356673-44361513
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Data sourse: ENCSR000BLD, GSE67783, GSE86191, GSE98367, GSE110061, GSE129526, GSE111913, GSE206145, GSE206145-NatGen2015, GSE50893, GSE120943, ENCSR153HNT, GSE103477, GSE111537, GSE25021, GSE108869, GSE126755
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Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Monocytes, GM2610, THP-1, GM12891, OCI-AML-3, HeLa-S3, RT-112, K-562, Neutrophil, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.822
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
74% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 28%,
"15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: TRIM25, XBP1, LEO1, MLL4, ATF3, ZBTB5, MITF, MAF, TRIM28, LMO2, ESR1, USF2, JUN, CTCF, MNT, E2F6, ZNF350, TFAP2C, EED, POU2F2, CHD8, MYCN, ID3, KDM4C, ZBTB48, STAT1, ERG, MYC, RFX1, GRHL3, NKX2-1, STAT3, DNMT3B, ESRRA, EZH2, GRHL2, ZHX2, SPI1, NFYB, ETV5, CC2D1A, RUNX1, EZH2phosphoT487, SIRT6, ZFX, TET2, PRDM10, CREBBP, ZNF384, ATF2, ZNF48, NFYA, FOXM1, SP2, FOS, MYB, C11orf30, L3MBTL2, SETDB1, STAT5A, USF1, REST, ZNF479, RBM25, AATF, STAG1, NFATC3, TRP47, FOXA2, CBX3, ZSCAN16, WT1, MEF2C, HOXB13, YY1, RELA, AHR, SP140, TCF4, HIF1A, MGA, MAF1, MAX, SPIB, PLAG1, KDM5B, TP53, PKNOX1, ZNF334, NFKB1, AR, ZNF445, HEXIM1, HSF1, RNF2, BRD4, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): UBE2G2,TRPM2,ADARB1,TSPEAR,LRRC3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 116
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000142185,
ENSG00000160233,
ENSG00000175894,
ENSG00000184787,
ENSG00000197381,
- Related loop:
chr21:43200000-43225000~~chr21:44350000-44375000,
chr21:44350000-44375000~~chr21:44450000-44475000,
chr21:44350000-44375000~~chr21:44475000-44500000,
chr21:44350000-44375000~~chr21:44725000-44750000,
chr21:44350000-44375000~~chr21:44750000-44775000,
chr21:44350000-44375000~~chr21:44775000-44800000,
chr21:44350000-44375000~~chr21:45125000-45150000,
chr21:44350000-44375000~~chr21:45200000-45225000,