- Basic information
- CohesinDB ID: CDBP00420981
- Locus: chr21-44374000-44381319
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Data sourse: ENCSR000BLD, GSE72082, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE115602, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE115250, GSE138405, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, ENCSR703TNG, GSE106870, GSE145327, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, GSE38411
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Cell type: RH4, CVB-hiPSC, OCI-AML-3, TC-32, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, K-562, BCBL-1, DKO, H1-hESC, Monocytes, MB157, GM12891, SK-N-SH, RT-112, THP-1, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, Neurons-H1, HeLa, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 19% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.667
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
74% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 25%,
"15_Quies": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, FOXO1, PGR, XBP1, PATZ1, FOXA1, SUZ12, LEO1, ZFHX2, LYL1, ZNF90, ATF3, ZBTB5, RUNX3, CHD7, ZNF444, CBFB, MECOM, TP63, ZNF320, BACH2, ZNF467, JMJD1C, MAF, ELF1, TRIM28, TEAD1, RBM39, LMO2, ESR1, MLL, OCA2, USF2, CTCF, TCF12, JUN, EP300, KLF1, LMO1, MNT, E2F6, TRIM24, KMT2B, GATAD2A, TFAP2C, EED, GLIS1, POU2F2, CHD8, NANOG, ZSCAN5D, MYCN, ZNF263, RUNX1T1, POU5F1, TOP2A, CTBP1, ZBTB48, ZSCAN5A, STAT1, MLLT3, SRF, ERG2, ZNF300, ERG, PBX1, ASCL1, OGG1, MYC, RAD21, GRHL3, GABPA, STAT3, XRCC5, PRDM14, IKZF1, NFE2, DNMT3B, VDR, NR3C1, CEBPB, STAT5B, KMT2A, EZH2, GRHL2, FEZF1, SPI1, PCBP1, GATA2, INTS13, FLI1, HCFC1R1, NCOA2, ETV5, RUNX1, SMC1A, BCL6, CEBPA, EZH2phosphoT487, CBX1, ZFX, ZNF534, TET2, ERG3, TRIM22, RARA, ZBTB2, CREBBP, ARNT, BACH1, ATF2, SMAD4, ETV6, SMARCB1, CDK8, CHD1, HMGXB4, MED1, TEAD3, ZEB1, MYB, SMAD1, NCOA1, EVI1, SETDB1, STAT5A, SREBF2, MAFK, SP1, BCL11A, NR4A1, REST, ZBTB7A, ZNF479, POU2F3, HNRNPLL, TCF3, GLIS2, BCOR, AATF, SMC3, MLLT1, STAG1, SKI, TRP47, CBFA2T2, FOXA2, MTA3, EBF1, MEIS1, TBL1X, AGO1, RBBP5, ZNF692, ZNF600, WT1, MEF2C, CDK9, KDM1A, YY1, RELA, TARDBP, BRG1, MCM3, SP140, TCF4, HIF1A, ZIC2, GATA3, TAL1, MAX, NRIP1, ZNF143, ZNF333, ZFP69B, TCF7L2, NR2F1, TP53, MED, ZNF334, EGR2, T, TBX21, BHLHE40, AR, ARID4B, ZBTB16, RXR, EGR1, HEXIM1, HSF1, BRD4, SCRT1, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): PCBP3,TRPM2,LRRC3,ADARB1,UBE2G2,TSPEAR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 708
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000142185,
ENSG00000160233,
ENSG00000175894,
ENSG00000184787,
ENSG00000197381,
ENSG00000183570,
- Related loop:
chr21:43175000-43200000~~chr21:44375000-44400000,
chr21:43200000-43225000~~chr21:44350000-44375000,
chr21:43350000-43375000~~chr21:44375000-44400000,
chr21:44350000-44375000~~chr21:44450000-44475000,
chr21:44350000-44375000~~chr21:44475000-44500000,
chr21:44350000-44375000~~chr21:44725000-44750000,
chr21:44350000-44375000~~chr21:44750000-44775000,
chr21:44350000-44375000~~chr21:44775000-44800000,
chr21:44350000-44375000~~chr21:45125000-45150000,
chr21:44350000-44375000~~chr21:45200000-45225000,
chr21:44375000-44400000~~chr21:44475000-44500000,
chr21:44375000-44400000~~chr21:44725000-44750000,
chr21:44375000-44400000~~chr21:45725000-45750000,
chr21:44376561-44378522~~chr21:44438718-44440053,