Deatailed information for cohesin site CDBP00421000

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  • Basic information
  • CohesinDB ID: CDBP00421000
  • Locus: chr21-44423218-44429069
  • Data sourse: ENCSR000BLD, ShirahigeLab-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, GSE121355, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000BTU, GSE67783, GSE86191, GSE138405, ShirahigeLab-NatGen2015, GSE120943, ENCSR703TNG, ENCSR879KXD, ENCSR000BLS, ShirahigeLab, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE126990, GSE126755, ENCSR000ECS
  • Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, MB157, Monocytes, Ishikawa, HeLa-S3, RT-112, K-562, Liver, Neutrophil, HSPC, DKO
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 14% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.811
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 74% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 26%, "9_Het": 21%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: MBD3, FOXO1, TRIM25, PGR, SOX2, NME2, XBP1, KDM4B, FOXA1, PATZ1, SUZ12, RBFOX2, LEO1, PBX2, MLL4, ZFHX2, UBTF, SFMBT1, ZNF28, HDGF, ATF3, ZNF362, ZBTB5, CTCFL, ZNF444, CBFB, MORC2, TP63, MITF, ZNF736, KLF5, ELF1, TEAD1, TRIM28, ETV1, SNAI2, NFE2L2, LMO2, ESR1, HDAC8, USF2, CTCF, TAF3, TCF12, BAF155, EP300, KLF1, E4F1, ZNF695, E2F6, TRIM24, DEK, E2F4, E2F1, TEAD4, GTF2F1, TFAP2C, GLIS1, POU2F2, CHD8, ZSCAN5D, MYCN, ZNF263, POU5F1, KDM4C, TOP2A, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, ELK4, STAT1, DDX5, ERG2, SP4, TBP, ERG, PBX1, ASCL1, OGG1, ZNF341, MYC, EZH1, SMARCA4, RAD21, FOXP2, GRHL3, NKX2-1, GABPA, APC, STAT3, NKX3-1, PRDM14, RCOR1, DNMT3B, NR3C1, CEBPB, HNRNPL, KMT2A, CREB1, EZH2, KLF8, GRHL2, GABPB1, PHF8, ZHX2, SPI1, KDM5A, IRF1, PCBP1, GATA2, SSRP1, SREBF1, FLI1, HCFC1, MXI1, ZNF554, ATF1, ETV5, RUNX1, CTNNB1, BCL6, CBX1, HDAC1, EZH2phosphoT487, SIRT6, NKX2-2, SIN3A, ZFX, AFF4, TET2, ERG3, ZNF770, NFXL1, SMARCC1, CREBBP, ZNF384, TAF15, CDK6, GATA4, SP3, ARNT, NRF1, SOX11, CBX3, ZNF48, FOXM1, FOS, SMARCB1, CDK8, CHD1, MED1, CSNK2A1, TEAD3, ZEB1, KDM6B, SCRT2, PIAS1, ZNF3, NCOA1, L3MBTL2, EVI1, USF1, NIPBL, SP1, BCL11A, REST, ZBTB7A, ATF7, ZHX1, HNRNPLL, CTBP2, PHIP, TCF3, GLIS2, FOXP1, AATF, SMC3, ELL2, NCOR2, STAG1, ZNF394, NELFA, TRP47, ZNF316, AGO1, FOXA2, EBF1, MEIS1, MTA3, CHD2, ZNF600, PAF1, TBL1X, WT1, MAFF, CDK9, HOXB13, KDM1A, YY1, RELA, ZNF222, BRG1, MCM3, SP140, TCF4, ZIC2, HIF1A, ZFP36, BHLHE22, SKIL, MGA, MAX, ZNF449, ZNF143, PLAG1, KLF4, NCOA3, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, MED, ZNF334, EGR2, BRD2, AR, TAF1, ZBTB40, RXR, EGLN2, ZBTB42, HEXIM1, HSF1, ZBTB26, NCOR1, BRD4, SCRT1, JUND, CLOCK, MAZ, AHR
  • Target gene symbol (double-evidenced CRMs): TRPM2,RRP1,AGPAT3,CFAP410,TRAPPC10,PFKL
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 794
  • Number of somatic mutations (non-coding): 166
  • Related genes and loops
  • Related gene: ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185,
  • Related loop: chr21:43350000-43375000~~chr21:44425000-44450000, chr21:43800000-43825000~~chr21:44425000-44450000, chr21:43900000-43925000~~chr21:44425000-44450000, chr21:44050000-44075000~~chr21:44425000-44450000, chr21:44075000-44100000~~chr21:44425000-44450000, chr21:44325000-44350000~~chr21:44425000-44450000, chr21:5100000-5125000~~chr21:44425000-44450000,
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