Deatailed information for cohesin site CDBP00421003

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  • Basic information
  • CohesinDB ID: CDBP00421003
  • Locus: chr21-44432556-44445133
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, ENCSR000BTU, GSE93080, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE152721, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR000ECS, GSE38411
  • Cell type: MDM, RH4, GM10847, CVB-hiPSC, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, GM18951, SNYDER, MB157, GM12878, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HUVEC, GM19238, OCI-AML-3, HAP1
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 22% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.544
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 74% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 24%, "14_ReprPCWk": 21%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, PGR, HMG20A, SOX2, XBP1, FOXA1, SUZ12, RBFOX2, LEO1, RXRB, ZNF28, KDM3A, TFAP4, SIN3B, ATF3, BMI1, ZFP64, THAP1, CBFB, MORC2, MXD4, PAX5, TP63, ZNF736, ZNF506, TEAD1, TRIM28, ELF1, KLF6, RBM39, RCOR2, ESR1, PITX3, HDAC8, USF2, CTCF, JUN, TCF12, EP300, KLF1, MNT, SOX5, RYBP, E2F6, DMAP1, TRIM24, ZNF407, DEK, E2F4, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, TFAP2C, MLX, RBPJ, GLIS1, POU2F2, CHD8, ZSCAN5D, MYCN, ZNF263, RUNX1T1, ID3, POU5F1, CTBP1, TOP2A, ZBTB48, ZSCAN5A, STAT1, DUX4, SRF, GATAD1, DDX5, SAP130, ARID3A, SP4, ERG2, TBP, HNF4G, ERG, ASCL1, OGG1, MYC, SMARCA4, KDM4A, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, MCRS1, GABPA, STAT3, XRCC5, ZNF614, MIER3, DNMT3B, NR2F6, RCOR1, HNRNPH1, CEBPB, SRSF3, HNRNPL, CREB1, EZH2, KLF8, BMPR1A, ZNF652, EBF3, GABPB1, ZKSCAN5, SPI1, TFE3, MIXL1, HBP1, KLF17, PCBP1, HDAC2, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, MXI1, SMARCA5, HCFC1R1, NFIL3, NCOA2, MYF5, ATF1, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, EZH2phosphoT487, SIRT6, CBX1, SOX13, ZFX, SIN3A, CRY1, FIP1L1, SMAD3, PCBP2, TET2, ZNF770, ERG3, SP5, CBX8, TWIST1, PRDM10, CEBPZ, CREBBP, ZNF384, RARA, NFYC, TAF15, ZBTB2, ZNF133, CDK6, RUNX2, GATA4, ARNT, BACH1, ATF2, ZNF48, SMAD4, CBFA2T3, PBX3, CHD1, HMGXB4, CDK8, FOS, CSNK2A1, TEAD3, KDM6B, CEBPD, SCRT2, ZMYM3, SMAD1, PIAS1, ZNF3, U2AF1, NCOA1, L3MBTL2, SETDB1, SREBF2, STAT5A, RBM22, USF1, NIPBL, HNF4A, IKZF5, REST, ZBTB7A, NKX2-5, RBM25, ASH2L, HNRNPLL, NKX2-2, TCF3, BCOR, AATF, SMC3, STAG1, ETV4, SKI, TRP47, CBFA2T2, PPARG, AGO1, FOXA2, CBX3, MEIS1, PAF1, CHD2, ZNF600, MIER2, MTA3, WT1, NFATC1, MEF2C, ZNF580, ZKSCAN1, HOXB13, KDM1A, YY1, RELA, BCL3, TARDBP, BRG1, MCM3, SP140, ZFP36, HIF1A, ZIC2, TCF4, GATA3, MGA, TAL1, MAX, NRIP1, ZNF143, AGO2, GATA1, HAND2, PLAG1, CBX2, CEBPG, GFI1B, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, MED, ZNF334, MYOD1, EGR2, ELF3, PHF5A, KAT8, BRD2, NFKBIZ, AR, ARID4B, BHLHE40, RXR, YAP1, EGLN2, ZNF366, HEXIM1, ZBTB42, TFIIIC, HSF1, ZBTB26, RNF2, SCRT1, BRD4, MYNN, JUND, CUX1, MAZ, NCOR1, AHR
  • Target gene symbol (double-evidenced CRMs): PFKL,RRP1,TRAPPC10,CFAP410,TRPM2,AGPAT3
  • Function elements
  • Human SNPs: Non-tuberculous_mycobacterial_pulmonary_disease
  • Number of somatic mutations (coding): 1048
  • Number of somatic mutations (non-coding): 237
  • Related genes and loops
  • Related gene: ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185,
  • Related loop: chr21:43350000-43375000~~chr21:44425000-44450000, chr21:43350000-43375000~~chr21:44450000-44475000, chr21:43800000-43825000~~chr21:44425000-44450000, chr21:43800000-43825000~~chr21:44450000-44475000, chr21:43900000-43925000~~chr21:44425000-44450000, chr21:44025000-44050000~~chr21:44450000-44475000, chr21:44050000-44075000~~chr21:44425000-44450000, chr21:44050000-44075000~~chr21:44450000-44475000, chr21:44075000-44100000~~chr21:44425000-44450000, chr21:44075000-44100000~~chr21:44450000-44475000, chr21:44325000-44350000~~chr21:44425000-44450000, chr21:44325000-44350000~~chr21:44450000-44475000, chr21:44350000-44375000~~chr21:44450000-44475000, chr21:44376561-44378522~~chr21:44438718-44440053, chr21:5100000-5125000~~chr21:44425000-44450000, chr21:5100000-5125000~~chr21:44450000-44475000,
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