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Basic information

CohesinDB ID: CDBP00421006

Locus: chr21-44448540-44449289

Data sourse: GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 30%, "15_Quies": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, PGR, HMG20A, SOX2, XBP1, FOXA1, SUZ12, RBFOX2, LEO1, RXRB, ZNF28, KDM3A, TFAP4, SIN3B, ATF3, BMI1, ZFP64, THAP1, CBFB, MORC2, MXD4, PAX5, TP63, ZNF736, ZNF506, TEAD1, TRIM28, ELF1, KLF6, RBM39, RCOR2, ESR1, PITX3, HDAC8, USF2, CTCF, JUN, TCF12, EP300, KLF1, MNT, SOX5, RYBP, E2F6, DMAP1, TRIM24, ZNF407, DEK, E2F4, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, TFAP2C, MLX, RBPJ, GLIS1, POU2F2, CHD8, ZSCAN5D, MYCN, ZNF263, RUNX1T1, ID3, POU5F1, CTBP1, TOP2A, ZBTB48, ZSCAN5A, STAT1, DUX4, SRF, GATAD1, DDX5, SAP130, ARID3A, SP4, ERG2, TBP, HNF4G, ERG, ASCL1, OGG1, MYC, SMARCA4, KDM4A, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, MCRS1, GABPA, STAT3, XRCC5, ZNF614, MIER3, DNMT3B, NR2F6, RCOR1, HNRNPH1, CEBPB, SRSF3, HNRNPL, CREB1, EZH2, KLF8, BMPR1A, ZNF652, EBF3, GABPB1, ZKSCAN5, SPI1, TFE3, MIXL1, HBP1, KLF17, PCBP1, HDAC2, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, MXI1, SMARCA5, HCFC1R1, NFIL3, NCOA2, MYF5, ATF1, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, EZH2phosphoT487, SIRT6, CBX1, SOX13, ZFX, SIN3A, CRY1, FIP1L1, SMAD3, PCBP2, TET2, ZNF770, ERG3, SP5, CBX8, TWIST1, PRDM10, CEBPZ, CREBBP, ZNF384, RARA, NFYC, TAF15, ZBTB2, ZNF133, CDK6, RUNX2, GATA4, ARNT, BACH1, ATF2, ZNF48, SMAD4, CBFA2T3, PBX3, CHD1, HMGXB4, CDK8, FOS, CSNK2A1, TEAD3, KDM6B, CEBPD, SCRT2, ZMYM3, SMAD1, PIAS1, ZNF3, U2AF1, NCOA1, L3MBTL2, SETDB1, SREBF2, STAT5A, RBM22, USF1, NIPBL, HNF4A, IKZF5, REST, ZBTB7A, NKX2-5, RBM25, ASH2L, HNRNPLL, NKX2-2, TCF3, BCOR, AATF, SMC3, STAG1, ETV4, SKI, TRP47, CBFA2T2, PPARG, AGO1, FOXA2, CBX3, MEIS1, PAF1, CHD2, ZNF600, MIER2, MTA3, WT1, NFATC1, MEF2C, ZNF580, ZKSCAN1, HOXB13, KDM1A, YY1, RELA, BCL3, TARDBP, BRG1, MCM3, SP140, ZFP36, HIF1A, ZIC2, TCF4, GATA3, MGA, TAL1, MAX, NRIP1, ZNF143, AGO2, GATA1, HAND2, PLAG1, CBX2, CEBPG, GFI1B, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, MED, ZNF334, MYOD1, EGR2, ELF3, PHF5A, KAT8, BRD2, NFKBIZ, AR, ARID4B, BHLHE40, RXR, YAP1, EGLN2, ZNF366, HEXIM1, ZBTB42, TFIIIC, HSF1, ZBTB26, RNF2, SCRT1, BRD4, MYNN, JUND, CUX1, MAZ, NCOR1, AHR

Target gene symbol (double-evidenced CRMs): CFAP410,PFKL,TRPM2,TRAPPC10,RRP1,AGPAT3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185,

eachgene

Deatailed information for cohesin site CDBP00421006