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Basic information

CohesinDB ID: CDBP00421008

Locus: chr21-44454404-44458504

Data sourse: ENCSR230ZWH, ENCSR000BSB, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE64758, ENCSR000BLD, GSE126634, GSE103477, GSE108869, GSE138405, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE110061, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000BTU, ENCSR000DZP, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, B-cell, H9-hESC, GM2630, RPE, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, THP-1, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 52% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.378

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "1_TssA": 15%, "14_ReprPCWk": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, KDM3A, ZBTB7B, HDGF, THAP1, MORC2, PAX5, TEAD1, LMO2, OCA2, MED26, ZNF561, SOX5, DEK, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, HHEX, CTBP1, STAT1, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1R1, RUVBL2, RUNX1, CEBPA, CRY1, TET2, TBX3, SP5, SMARCC1, PRDM10, ZBTB2, SP2, SMARCB1, PIAS1, EVI1, MBD1, IKZF5, ARID2, RBM25, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, ZNF207, CREM, CHD2, SS18, PAF1, WT1, NEUROD1, MCM3, ZFP36, ZNF311, PLAG1, KLF4, BCL11B, ZNF281, ZBTB6, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, ZBTB26, HSF1, SCRT1, FOSL1, XBP1, PBX2, ATF3, THRB, ZFP64, CBFB, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, ELF1, RBM39, KLF10, FUS, JUN, CTCF, L3MBTL4, LMO1, MNT, RYBP, IRF4, PDX1, TFAP2C, RBPJ, MLX, ZNF239, ZNF317, ZBTB17, ZBTB48, NONO, SRF, DDX5, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, ZBTB14, SSRP1, NFIL3, THAP11, EZH2phosphoT487, SOX13, SP3, ARNT, BACH1, NFIB, ZNF48, PRDM9, HMBOX1, PBX3, NCAPH2, HMGXB4, TEAD3, ZXDB, U2AF1, KLF9, USF1, SP1, BCL11A, TFAP2A, ZNF479, ASH2L, GLIS2, SMC3, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, KLF15, TAL1, NRIP1, ZNF143, AGO2, CBX2, ZNF141, TP53, ZNF334, ZSCAN22, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZNF468, PGR, PATZ1, TFAP4, SIN3B, BMI1, ZNF444, MXD4, SMARCE1, KLF6, NFE2L2, ESR1, KLF1, ZNF695, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, ZSCAN5A, ERG2, SP4, HIC1, TBP, HNF4G, OGG1, SMARCC2, ETS1, MYC, KLF12, MCRS1, GABPA, STAT3, INO80, DNMT3B, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, ERG3, MYBL2, RARA, CREBBP, NFYC, ZNF384, TAF15, SMAD4, CDK8, ZEB1, ZMYM3, SREBF2, RBM22, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, HDAC6, ZNF692, GTF2B, FOXO3, RELA, TARDBP, MAX, ZNF592, NR2F1, TCF7L2, KDM5B, AR, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, SUZ12, RBFOX2, ZNF28, ZFHX2, ZNF90, NFIC, CTCFL, PRDM1, KLF14, MECOM, ZNF736, KLF5, TRIM28, RCOR2, MLL, USF2, TCF12, BAF155, EP300, GLI4, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ARID3A, ZNF300, ASCL1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, FEZF1, TFE3, HBP1, IRF1, ZGPAT, MRTFB, ZC3H11A, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, PCBP2, CBX8, PRPF4, CDK6, SMAD2, GATA4, ZNF184, NRF1, CHD1, FOS, MED1, CEBPD, KDM6B, MYB, SCRT2, VEZF1, ZNF3, SETDB1, NIPBL, ZBTB7A, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, ZNF449, CEBPG, SP7, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): PFKL,RRP1,LRRC3,TRPM2,CFAP410,TRAPPC10

Function elements

Human SNPs: Intracranial_aneurysm

Number of somatic mutations (coding): 209

Number of somatic mutations (non-coding): 214

Related genes and loops

Related gene: ENSG00000160214, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233,

eachgene

Deatailed information for cohesin site CDBP00421008