Deatailed information for cohesin site CDBP00421009

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  • Basic information
  • CohesinDB ID: CDBP00421009
  • Locus: chr21-44458902-44463283
  • Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, GSE115602, ENCSR000BTU, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE116344, GSE138105, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000EHX, ENCSR635OSG, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, ENCSR000ECS
  • Cell type: RH4, SLK, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, K-562, DKO, MB157, SK-N-SH, RT-112, HeLa-Tet-On, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, HUVEC, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 17% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.744
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 74% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 28%, "5_TxWk": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, KDM3A, ZBTB7B, HDGF, THAP1, MORC2, PAX5, TEAD1, LMO2, OCA2, MED26, ZNF561, SOX5, DEK, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, HHEX, CTBP1, STAT1, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1R1, RUVBL2, RUNX1, CEBPA, CRY1, TET2, TBX3, SP5, SMARCC1, PRDM10, ZBTB2, SP2, SMARCB1, PIAS1, EVI1, MBD1, IKZF5, ARID2, RBM25, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, ZNF207, CREM, CHD2, SS18, PAF1, WT1, NEUROD1, MCM3, ZFP36, ZNF311, PLAG1, KLF4, BCL11B, ZNF281, ZBTB6, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, ZBTB26, HSF1, SCRT1, FOSL1, XBP1, PBX2, ATF3, THRB, ZFP64, CBFB, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, ELF1, RBM39, KLF10, FUS, JUN, CTCF, L3MBTL4, LMO1, MNT, RYBP, IRF4, PDX1, TFAP2C, RBPJ, MLX, ZNF239, ZNF317, ZBTB17, ZBTB48, NONO, SRF, DDX5, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, ZBTB14, SSRP1, NFIL3, THAP11, EZH2phosphoT487, SOX13, SP3, ARNT, BACH1, NFIB, ZNF48, PRDM9, HMBOX1, PBX3, NCAPH2, HMGXB4, TEAD3, ZXDB, U2AF1, KLF9, USF1, SP1, BCL11A, TFAP2A, ZNF479, ASH2L, GLIS2, SMC3, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, KLF15, TAL1, NRIP1, ZNF143, AGO2, CBX2, ZNF141, TP53, ZNF334, ZSCAN22, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZNF468, PGR, PATZ1, TFAP4, SIN3B, BMI1, ZNF444, MXD4, SMARCE1, KLF6, NFE2L2, ESR1, KLF1, ZNF695, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, ZSCAN5A, ERG2, SP4, HIC1, TBP, HNF4G, OGG1, SMARCC2, ETS1, MYC, KLF12, MCRS1, GABPA, STAT3, INO80, DNMT3B, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, ERG3, MYBL2, RARA, CREBBP, NFYC, ZNF384, TAF15, SMAD4, CDK8, ZEB1, ZMYM3, SREBF2, RBM22, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, HDAC6, ZNF692, GTF2B, FOXO3, RELA, TARDBP, MAX, ZNF592, NR2F1, TCF7L2, KDM5B, AR, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, SUZ12, RBFOX2, ZNF28, ZFHX2, ZNF90, NFIC, CTCFL, PRDM1, KLF14, MECOM, ZNF736, KLF5, TRIM28, RCOR2, MLL, USF2, TCF12, BAF155, EP300, GLI4, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ARID3A, ZNF300, ASCL1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, FEZF1, TFE3, HBP1, IRF1, ZGPAT, MRTFB, ZC3H11A, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, PCBP2, CBX8, PRPF4, CDK6, SMAD2, GATA4, ZNF184, NRF1, CHD1, FOS, MED1, CEBPD, KDM6B, MYB, SCRT2, VEZF1, ZNF3, SETDB1, NIPBL, ZBTB7A, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, ZNF449, CEBPG, SP7, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): CFAP410,PFKL,RRP1,LRRC3,TRPM2,TRAPPC10
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 23
  • Number of somatic mutations (non-coding): 15
  • Related genes and loops
  • Related gene: ENSG00000160214, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233,
  • Related loop: chr21:43350000-43375000~~chr21:44450000-44475000, chr21:43800000-43825000~~chr21:44450000-44475000, chr21:44025000-44050000~~chr21:44450000-44475000, chr21:44050000-44075000~~chr21:44450000-44475000, chr21:44075000-44100000~~chr21:44450000-44475000, chr21:44325000-44350000~~chr21:44450000-44475000, chr21:44350000-44375000~~chr21:44450000-44475000, chr21:5100000-5125000~~chr21:44450000-44475000,
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