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Basic information

CohesinDB ID: CDBP00421017

Locus: chr21-44488757-44489043

Data sourse: GSE110061, GSE86191

Cell type: HCT-116

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.989

Subunit: Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 74% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 44%, "14_ReprPCWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, PGR, TRIM25, FANCL, HMG20A, SOX2, MEIS2, XBP1, FOXA1, SUZ12, RBFOX2, RXRB, PBX2, UBTF, ZFHX2, KDM3A, TFAP4, ATF3, ZFP64, CBFB, MXD4, MECOM, MITF, ZNF320, ZNF467, JMJD1C, ZNF506, TEAD1, TRIM28, ZNF573, RBM39, KLF6, ELF1, ETV1, ESR1, OCA2, TP73, USF2, ZNF561, CTCF, JUN, E4F1, KLF1, SOX5, GATA6, E2F6, DMAP1, TRIM24, RAD51, ZNF528, ZNF280A, TEAD4, FOXA3, GTF2F1, GATAD2A, RBPJ, TFAP2C, EED, GLIS1, PDX1, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, POU5F1, ID3, RUNX1T1, TOP2A, ZSCAN21, ZBTB48, DUX4, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ERG2, TBP, ERG, PBX1, ASCL1, OGG1, ZNF341, ETS1, MYC, EZH1, SMARCA4, KDM4A, HOMEZ, RAD21, GRHL3, STAT3, XRCC5, APC, ZNF614, MIER3, DNMT3B, HNRNPH1, NR2F6, ARNTL, CEBPB, SRSF3, HNRNPL, KMT2A, CREB1, CCAR2, EZH2, ZNF565, GABPB1, SPI1, TFE3, MIXL1, IRF1, PCBP1, HDAC2, GATA2, MXD3, FLI1, DRAP1, ZGPAT, HCFC1R1, NFIL3, MYF5, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, EZH2phosphoT487, NKX2-2, SIRT6, FIP1L1, ZFX, SIN3A, ZNF534, SOX13, TET2, ERG3, SMARCC1, ZBTB2, PRPF4, ZNF384, ZNF133, CREBBP, RARA, NFYC, TAF15, GATA4, ARNT, SOX11, ZNF48, ATF2, ZNF518A, HMGB2, SMAD4, ETV6, MAFB, NCAPH2, CHD1, FOS, HMGXB4, CDK8, MED1, GMEB1, TEAD3, ZEB1, CEBPD, MYB, SCRT2, PIAS1, ZMYM3, U2AF1, TERF1, KLF9, SETDB1, TBX5, ZNF22, RBM22, USF1, BCL11A, MAFK, NKX2-5, REST, IKZF5, ZBTB7A, RBM25, POU2F3, ASH2L, HNRNPLL, BCOR, TCF3, AATF, SMC3, STAG1, NFATC3, TRP47, ZNF283, CBFA2T2, PPARG, AGO1, CBX3, FOXA2, SS18, MIER2, WT1, MAFF, ZBTB33, CDK9, ZNF580, HOXB13, KDM1A, YY1, RELA, TARDBP, BRG1, SP140, ZFP36, HIF1A, ZIC2, GATA3, MAX, GATA1, ZNF143, AGO2, CBX2, PLAG1, CEBPG, NR2F1, KDM5B, TP53, RUVBL1, ZNF334, MYOD1, EGR2, ELF3, KAT8, ARRB1, ARID4B, AR, PAX3-FOXO1, NFKBIZ, RXR, EGR1, HEXIM1, TFIIIC, ZBTB26, HSF1, NCOR1, BRD4, RNF2, SCRT1, CUX1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): UBE2G2,PWP2,HSF2BP,ITGB2,PFKL,DNMT3L,PDXK,TRAPPC10,CSTB,TRPM2,ITGB2-AS1,CFAP410,PCBP3,TSPEAR,AGPAT3,GATD3A,ADARB1,FAM207A,PTTG1IP,RRP1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160207, ENSG00000160209, ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000241945, ENSG00000160221, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421017