- Basic information
- CohesinDB ID: CDBP00421022
- Locus: chr21-44498019-44500523
-
Data sourse: ENCSR167MTG, ENCSR338DUC, GSE67783, GSE72082, GSE86191, GSE116868, GSE111913, ENCSR000BLS, GSE206145, ENCSR054FKH, ENCSR153HNT, GSE25021
-
Cell type: RPE, HCT-116, MB157, Hep-G2, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SA2,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
77% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"14_ReprPCWk": 35%,
"15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, FOSL1, PGR, TRIM25, FANCL, HMG20A, SOX2, MEIS2, XBP1, FOXA1, SUZ12, RBFOX2, RXRB, PBX2, UBTF, ZFHX2, KDM3A, TFAP4, ATF3, ZFP64, CBFB, MXD4, MECOM, MITF, ZNF320, ZNF467, JMJD1C, ZNF506, TEAD1, TRIM28, ZNF573, RBM39, KLF6, ELF1, ETV1, ESR1, OCA2, TP73, USF2, ZNF561, CTCF, JUN, E4F1, KLF1, SOX5, GATA6, E2F6, DMAP1, TRIM24, RAD51, ZNF528, ZNF280A, TEAD4, FOXA3, GTF2F1, GATAD2A, RBPJ, TFAP2C, EED, GLIS1, PDX1, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, POU5F1, ID3, RUNX1T1, TOP2A, ZSCAN21, ZBTB48, DUX4, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ERG2, TBP, ERG, PBX1, ASCL1, OGG1, ZNF341, ETS1, MYC, EZH1, SMARCA4, KDM4A, HOMEZ, RAD21, GRHL3, STAT3, XRCC5, APC, ZNF614, MIER3, DNMT3B, HNRNPH1, NR2F6, ARNTL, CEBPB, SRSF3, HNRNPL, KMT2A, CREB1, CCAR2, EZH2, ZNF565, GABPB1, SPI1, TFE3, MIXL1, IRF1, PCBP1, HDAC2, GATA2, MXD3, FLI1, DRAP1, ZGPAT, HCFC1R1, NFIL3, MYF5, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, EZH2phosphoT487, NKX2-2, SIRT6, FIP1L1, ZFX, SIN3A, ZNF534, SOX13, TET2, ERG3, SMARCC1, ZBTB2, PRPF4, ZNF384, ZNF133, CREBBP, RARA, NFYC, TAF15, GATA4, ARNT, SOX11, ZNF48, ATF2, ZNF518A, HMGB2, SMAD4, ETV6, MAFB, NCAPH2, CHD1, FOS, HMGXB4, CDK8, MED1, GMEB1, TEAD3, ZEB1, CEBPD, MYB, SCRT2, PIAS1, ZMYM3, U2AF1, TERF1, KLF9, SETDB1, TBX5, ZNF22, RBM22, USF1, BCL11A, MAFK, NKX2-5, REST, IKZF5, ZBTB7A, RBM25, POU2F3, ASH2L, HNRNPLL, BCOR, TCF3, AATF, SMC3, STAG1, NFATC3, TRP47, ZNF283, CBFA2T2, PPARG, AGO1, CBX3, FOXA2, SS18, MIER2, WT1, MAFF, ZBTB33, CDK9, ZNF580, HOXB13, KDM1A, YY1, RELA, TARDBP, BRG1, SP140, ZFP36, HIF1A, ZIC2, GATA3, MAX, GATA1, ZNF143, AGO2, CBX2, PLAG1, CEBPG, NR2F1, KDM5B, TP53, RUVBL1, ZNF334, MYOD1, EGR2, ELF3, KAT8, ARRB1, ARID4B, AR, PAX3-FOXO1, NFKBIZ, RXR, EGR1, HEXIM1, TFIIIC, ZBTB26, HSF1, NCOR1, BRD4, RNF2, SCRT1, CUX1, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): ITGB2,ITGB2-AS1,PTTG1IP,PKNOX1,FAM207A,RRP1,TSPEAR,PDXK,DNMT3L,CBS,PFKL,TRAPPC10,GATD3A,AGPAT3,PWP2,COL18A1,HSF2BP,ADARB1,CSTB,UBE2G2,PCBP3,TRPM2,CFAP410
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 189
- Number of somatic mutations (non-coding): 63
- Related genes and loops
- Related gene:
ENSG00000160199,
ENSG00000160200,
ENSG00000160207,
ENSG00000160209,
ENSG00000160213,
ENSG00000160214,
ENSG00000160216,
ENSG00000160218,
ENSG00000241945,
ENSG00000160221,
ENSG00000142182,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000175894,
ENSG00000184787,
ENSG00000183255,
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
ENSG00000197381,
ENSG00000182871,
ENSG00000183570,
- Related loop:
chr21:43025000-43050000~~chr21:44500000-44525000,
chr21:43300000-43325000~~chr21:44475000-44500000,
chr21:43575000-43600000~~chr21:44475000-44500000,
chr21:43750000-43775000~~chr21:44475000-44500000,
chr21:43800000-43825000~~chr21:44475000-44500000,
chr21:43825000-43850000~~chr21:44475000-44500000,
chr21:43900000-43925000~~chr21:44475000-44500000,
chr21:44000000-44025000~~chr21:44475000-44500000,
chr21:44050000-44075000~~chr21:44475000-44500000,
chr21:44075000-44100000~~chr21:44475000-44500000,
chr21:44125000-44150000~~chr21:44475000-44500000,
chr21:44150000-44175000~~chr21:44475000-44500000,
chr21:44250000-44275000~~chr21:44475000-44500000,
chr21:44325000-44350000~~chr21:44475000-44500000,
chr21:44350000-44375000~~chr21:44475000-44500000,
chr21:44375000-44400000~~chr21:44475000-44500000,
chr21:44475000-44500000~~chr21:44575000-44600000,
chr21:44475000-44500000~~chr21:44650000-44675000,
chr21:44475000-44500000~~chr21:44725000-44750000,
chr21:44475000-44500000~~chr21:44775000-44800000,
chr21:44475000-44500000~~chr21:44875000-44900000,
chr21:44475000-44500000~~chr21:44925000-44950000,
chr21:44475000-44500000~~chr21:44975000-45000000,
chr21:44475000-44500000~~chr21:45125000-45150000,
chr21:44475000-44500000~~chr21:45325000-45350000,
chr21:44475000-44500000~~chr21:45625000-45650000,
chr21:44500000-44525000~~chr21:44600000-44625000,
chr21:44500000-44525000~~chr21:44700000-44725000,
chr21:44500000-44525000~~chr21:44725000-44750000,
chr21:44500000-44525000~~chr21:44750000-44775000,
chr21:44500000-44525000~~chr21:44775000-44800000,
chr21:44500000-44525000~~chr21:44875000-44900000,
chr21:44500000-44525000~~chr21:44900000-44925000,
chr21:44500000-44525000~~chr21:44925000-44950000,
chr21:44500000-44525000~~chr21:44975000-45000000,
chr21:44500000-44525000~~chr21:45050000-45075000,
chr21:44500000-44525000~~chr21:45125000-45150000,
chr21:44500000-44525000~~chr21:45200000-45225000,
chr21:44500000-44525000~~chr21:45325000-45350000,
chr21:44500000-44525000~~chr21:45450000-45475000,
chr21:44500000-44525000~~chr21:45725000-45750000,
chr21:44505181-44506574~~chr21:44792488-44794438,
chr21:5100000-5125000~~chr21:44475000-44500000,