- Basic information
- CohesinDB ID: CDBP00421024
- Locus: chr21-44502563-44504881
-
Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE103477, GSE126755, GSE131577
-
Cell type: RPE, Fibroblast, HCT-116, HL-60, THP-1, RT-112, K-562, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: SMC3,SA1,Rad21,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"14_ReprPCWk": 44%,
"15_Quies": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: NFIA, FOSL1, PGR, TRIM25, FANCL, HMG20A, SOX2, MEIS2, XBP1, FOXA1, SUZ12, RBFOX2, RXRB, PBX2, UBTF, ZFHX2, KDM3A, TFAP4, ATF3, ZFP64, CBFB, MXD4, MECOM, MITF, ZNF320, ZNF467, JMJD1C, ZNF506, TEAD1, TRIM28, ZNF573, RBM39, KLF6, ELF1, ETV1, ESR1, OCA2, TP73, USF2, ZNF561, CTCF, JUN, E4F1, KLF1, SOX5, GATA6, E2F6, DMAP1, TRIM24, RAD51, ZNF528, ZNF280A, TEAD4, FOXA3, GTF2F1, GATAD2A, RBPJ, TFAP2C, EED, GLIS1, PDX1, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, POU5F1, ID3, RUNX1T1, TOP2A, ZSCAN21, ZBTB48, DUX4, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ERG2, TBP, ERG, PBX1, ASCL1, OGG1, ZNF341, ETS1, MYC, EZH1, SMARCA4, KDM4A, HOMEZ, RAD21, GRHL3, STAT3, XRCC5, APC, ZNF614, MIER3, DNMT3B, HNRNPH1, NR2F6, ARNTL, CEBPB, SRSF3, HNRNPL, KMT2A, CREB1, CCAR2, EZH2, ZNF565, GABPB1, SPI1, TFE3, MIXL1, IRF1, PCBP1, HDAC2, GATA2, MXD3, FLI1, DRAP1, ZGPAT, HCFC1R1, NFIL3, MYF5, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, EZH2phosphoT487, NKX2-2, SIRT6, FIP1L1, ZFX, SIN3A, ZNF534, SOX13, TET2, ERG3, SMARCC1, ZBTB2, PRPF4, ZNF384, ZNF133, CREBBP, RARA, NFYC, TAF15, GATA4, ARNT, SOX11, ZNF48, ATF2, ZNF518A, HMGB2, SMAD4, ETV6, MAFB, NCAPH2, CHD1, FOS, HMGXB4, CDK8, MED1, GMEB1, TEAD3, ZEB1, CEBPD, MYB, SCRT2, PIAS1, ZMYM3, U2AF1, TERF1, KLF9, SETDB1, TBX5, ZNF22, RBM22, USF1, BCL11A, MAFK, NKX2-5, REST, IKZF5, ZBTB7A, RBM25, POU2F3, ASH2L, HNRNPLL, BCOR, TCF3, AATF, SMC3, STAG1, NFATC3, TRP47, ZNF283, CBFA2T2, PPARG, AGO1, CBX3, FOXA2, SS18, MIER2, WT1, MAFF, ZBTB33, CDK9, ZNF580, HOXB13, KDM1A, YY1, RELA, TARDBP, BRG1, SP140, ZFP36, HIF1A, ZIC2, GATA3, MAX, GATA1, ZNF143, AGO2, CBX2, PLAG1, CEBPG, NR2F1, KDM5B, TP53, RUVBL1, ZNF334, MYOD1, EGR2, ELF3, KAT8, ARRB1, ARID4B, AR, PAX3-FOXO1, NFKBIZ, RXR, EGR1, HEXIM1, TFIIIC, ZBTB26, HSF1, NCOR1, BRD4, RNF2, SCRT1, CUX1, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): TSPEAR,PCBP3,COL18A1,CBS,ADARB1,FAM207A,ITGB2-AS1,UBE2G2,PKNOX1,ITGB2,PTTG1IP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 141
- Number of somatic mutations (non-coding): 47
- Related genes and loops
- Related gene:
ENSG00000160199,
ENSG00000160200,
ENSG00000175894,
ENSG00000184787,
ENSG00000183255,
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
ENSG00000197381,
ENSG00000182871,
ENSG00000183570,
- Related loop:
chr21:43025000-43050000~~chr21:44500000-44525000,
chr21:43300000-43325000~~chr21:44475000-44500000,
chr21:43575000-43600000~~chr21:44475000-44500000,
chr21:43750000-43775000~~chr21:44475000-44500000,
chr21:43800000-43825000~~chr21:44475000-44500000,
chr21:43825000-43850000~~chr21:44475000-44500000,
chr21:43900000-43925000~~chr21:44475000-44500000,
chr21:44000000-44025000~~chr21:44475000-44500000,
chr21:44050000-44075000~~chr21:44475000-44500000,
chr21:44075000-44100000~~chr21:44475000-44500000,
chr21:44125000-44150000~~chr21:44475000-44500000,
chr21:44150000-44175000~~chr21:44475000-44500000,
chr21:44250000-44275000~~chr21:44475000-44500000,
chr21:44325000-44350000~~chr21:44475000-44500000,
chr21:44350000-44375000~~chr21:44475000-44500000,
chr21:44375000-44400000~~chr21:44475000-44500000,
chr21:44475000-44500000~~chr21:44575000-44600000,
chr21:44475000-44500000~~chr21:44650000-44675000,
chr21:44475000-44500000~~chr21:44725000-44750000,
chr21:44475000-44500000~~chr21:44775000-44800000,
chr21:44475000-44500000~~chr21:44875000-44900000,
chr21:44475000-44500000~~chr21:44925000-44950000,
chr21:44475000-44500000~~chr21:44975000-45000000,
chr21:44475000-44500000~~chr21:45125000-45150000,
chr21:44475000-44500000~~chr21:45325000-45350000,
chr21:44475000-44500000~~chr21:45625000-45650000,
chr21:44500000-44525000~~chr21:44600000-44625000,
chr21:44500000-44525000~~chr21:44700000-44725000,
chr21:44500000-44525000~~chr21:44725000-44750000,
chr21:44500000-44525000~~chr21:44750000-44775000,
chr21:44500000-44525000~~chr21:44775000-44800000,
chr21:44500000-44525000~~chr21:44875000-44900000,
chr21:44500000-44525000~~chr21:44900000-44925000,
chr21:44500000-44525000~~chr21:44925000-44950000,
chr21:44500000-44525000~~chr21:44975000-45000000,
chr21:44500000-44525000~~chr21:45050000-45075000,
chr21:44500000-44525000~~chr21:45125000-45150000,
chr21:44500000-44525000~~chr21:45200000-45225000,
chr21:44500000-44525000~~chr21:45325000-45350000,
chr21:44500000-44525000~~chr21:45450000-45475000,
chr21:44500000-44525000~~chr21:45725000-45750000,
chr21:44505181-44506574~~chr21:44792488-44794438,
chr21:44509093-44511625~~chr21:44741922-44743349,
chr21:44509121-44511913~~chr21:44741499-44743338,
chr21:44509121-44511913~~chr21:44792385-44794491,
chr21:44509121-44511913~~chr21:44931981-44933531,
chr21:44509161-44511662~~chr21:44741531-44743454,
chr21:44509188-44511574~~chr21:44792239-44794440,
chr21:44509189-44512062~~chr21:44741776-44743366,
chr21:44509189-44512062~~chr21:44792150-44794532,
chr21:44509195-44511716~~chr21:44792591-44794447,
chr21:44509197-44511724~~chr21:44717965-44719686,
chr21:44509197-44511724~~chr21:44742007-44743217,
chr21:44509197-44511724~~chr21:44792559-44794303,
chr21:44509198-44511827~~chr21:44741970-44743275,
chr21:44509207-44511848~~chr21:44741832-44743353,
chr21:44509207-44511848~~chr21:44792389-44794429,
chr21:44509213-44512100~~chr21:44718108-44719341,
chr21:44509213-44512100~~chr21:44741837-44743290,
chr21:44509213-44512100~~chr21:44792156-44794493,
chr21:44509213-44512100~~chr21:44930976-44933923,
chr21:44509225-44511899~~chr21:44717741-44719707,
chr21:44509225-44511899~~chr21:44741727-44743366,
chr21:44509225-44511899~~chr21:44760944-44762448,
chr21:44509225-44511899~~chr21:44792192-44794515,
chr21:44509231-44511792~~chr21:44741857-44743273,
chr21:44509235-44511954~~chr21:44792155-44794858,
chr21:44509236-44511997~~chr21:44741562-44743367,
chr21:44509236-44511997~~chr21:44792073-44794483,
chr21:44509239-44511525~~chr21:44741601-44743335,
chr21:44509239-44511525~~chr21:44792488-44794374,
chr21:44509242-44511652~~chr21:44792257-44794053,
chr21:44509243-44511788~~chr21:44741569-44743400,
chr21:44509243-44511788~~chr21:44792303-44794463,
chr21:44509249-44511508~~chr21:44741746-44743390,
chr21:44509258-44511514~~chr21:44792553-44794330,
chr21:44509258-44511514~~chr21:45136441-45138077,
chr21:44509259-44511819~~chr21:44741806-44743375,
chr21:44509266-44512046~~chr21:44741597-44743406,
chr21:44509266-44512046~~chr21:44792219-44794436,
chr21:44509273-44511642~~chr21:44792534-44794311,
chr21:44509284-44511597~~chr21:44741782-44743295,
chr21:44509284-44511597~~chr21:44792564-44794485,
chr21:44509310-44511786~~chr21:44792445-44794502,
chr21:44509377-44511681~~chr21:44792242-44794455,
chr21:44509457-44512145~~chr21:44792168-44794432,
chr21:44509481-44512016~~chr21:44717736-44719579,
chr21:44509481-44512016~~chr21:44792235-44794464,
chr21:44509488-44511948~~chr21:44741900-44743346,
chr21:44509488-44511948~~chr21:44792109-44794449,
chr21:44509488-44511948~~chr21:44931870-44933936,
chr21:44509542-44511909~~chr21:44748109-44749367,
chr21:44509542-44511909~~chr21:44792296-44794494,
chr21:44509542-44511909~~chr21:44939138-44940511,
chr21:44509599-44512047~~chr21:44792203-44794435,
chr21:44509689-44512016~~chr21:44741924-44743372,
chr21:44509689-44512016~~chr21:44792155-44794487,
chr21:44509692-44511946~~chr21:44741525-44743441,
chr21:44509692-44511946~~chr21:44792297-44794482,
chr21:44509704-44511783~~chr21:44792291-44794265,
chr21:44509706-44511793~~chr21:44792098-44794805,
chr21:44509743-44512037~~chr21:44792110-44794473,
chr21:44509755-44512096~~chr21:44741909-44743377,
chr21:44509755-44512096~~chr21:44931884-44933752,
chr21:44509835-44511664~~chr21:44792662-44794245,
chr21:44509871-44511501~~chr21:44792580-44794252,
chr21:44509875-44511428~~chr21:44792634-44794192,
chr21:44509876-44511623~~chr21:44741970-44743300,
chr21:44509876-44511623~~chr21:44792577-44794368,
chr21:44509876-44511623~~chr21:44931107-44933966,
chr21:5100000-5125000~~chr21:44475000-44500000,