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Basic information

CohesinDB ID: CDBP00421026

Locus: chr21-44507767-44517880

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE64758, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 80% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.122

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 80% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 22%, "15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, MORC2, PAX5, ZNF320, TEAD1, LMO2, PITX3, HDAC8, ZNF561, ZNF507, E4F1, SOX5, PAX8, ZNF407, DEK, E2F4, ZNF410, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, ZNF563, SAP130, ERG, NFKB2, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, ZNF8, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, NR2C2, HCFC1R1, EP400, RUVBL2, RUNX1, CEBPA, HDAC1, NKX2-2, CRY1, IRF3, ZNF658, TET2, ZNF654, ZNF473, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ATF2, FOXM1, SP2, SMARCB1, PIAS1, SMAD1, C11orf30, MBD1, STAT5A, GSPT2, IKZF5, ARID2, RBM25, MBD2, ETV4, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, NFATC1, SS18, PAF1, ZSCAN16, WT1, MEF2C, MPHOSPH8, CREB3L1, NEUROD1, MCM3, ZFP36, TCF4, ZNF311, BATF, PLAG1, ZFP69B, ZNF544, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, ZNF621, XBP1, KDM4B, PBX2, HNRNPK, TSC22D4, CDK2, THRB, ATF3, ZC3H8, ZFP64, RUNX3, WDHD1, CBFB, DPF1, TP63, ZSCAN4, MITF, BACH2, ZNF467, MAF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, CTCF, JUN, TAF3, L3MBTL4, MNT, ZBTB20, DPF2, IRF4, ZNF423, MLX, RBPJ, TFAP2C, YBX1, MTA2, ZBTB17, ZBTB48, NONO, UTX, SRF, DDX5, PHB2, TRIP13, ZNF2, HOMEZ, FOXP2, KDM4A, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, CCAR2, TBL1XR1, KLF8, ARHGAP35, GRHL2, EBF3, KDM5A, SSRP1, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, EZH2phosphoT487, LDB1, SOX13, AFF4, POU4F2, SP3, ARNT, NFIB, BACH1, ZNF48, PRDM9, ZEB2, NFYA, HMBOX1, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, ETV6, TEAD3, DIDO1, ZNF680, U2AF1, KLF9, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAG1, STAG2, MLLT1, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, ZNF19, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, CUX1, ZSCAN23, PGR, CBX5, SOX2, PATZ1, UBTF, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, KLF6, NFE2L2, ZNF217, ESR1, KLF1, SOX9, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ASH1L, ZSCAN5A, ERG2, SP4, TBP, HNF4G, OGG1, ETS1, MYC, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, YBX3, EZH2, ZNF652, PHF8, ZNF436, SPI1, ZNF786, PCBP1, HDAC2, INTS13, GATAD2B, ZNF777, NCOA2, ZNF76, ZNF554, NFYB, ETV5, SALL2, BCL6, SIN3A, ERG3, MYBL2, RARA, NFYC, CREBBP, ZNF35, TAF15, ZNF384, ZNF354B, ZNF169, SMAD4, ZNF518A, CDK8, ZEB1, ZMYM3, GTF3C2, SREBF2, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, ZNF692, ZNF30, ZNF574, ZNF662, TCF7, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF791, PKNOX1, MYOD1, PAX3-FOXO1, AR, YAP1, ZNF324, HEXIM1, AHR, DMAP1, FOSL2, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF90, INSM2, NFIC, CTCFL, ZBTB5, PRDM1, KLF14, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, GATA6, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ID3, GATAD1, ARID3A, ASCL1, USP7, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, TCF25, ZNF639, ZNF667, HES1, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, ZIM3, MYF5, ATF1, PTBP1, CBX1, SMC1A, MAFG, SIRT6, FIP1L1, ZNF335, ZFX, ZNF534, SMAD3, PCBP2, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, PBX4, NR2C1, FOS, CHD1, TGIF2, MED1, CEBPD, KDM6B, SCRT2, MYB, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, SKI, NELFA, ZNF283, KLF13, FOXA2, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF148, BRCA1, SP140, HIF1A, BHLHE22, OTX2, ZNF519, ZNF740, TLE3, CEBPG, SP7, NCOA3, ZNF687, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB42, MYNN, ZNF248, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): COL18A1,PTTG1IP,FAM207A,ITGB2-AS1,TSPEAR,CBS,ITGB2,UBE2G2,PCBP3,PKNOX1,ADARB1

Function elements

Human SNPs: Balding_type_1

Number of somatic mutations (coding): 303

Number of somatic mutations (non-coding): 97

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160200, ENSG00000175894, ENSG00000184787, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421026