- Basic information
- CohesinDB ID: CDBP00421039
- Locus: chr21-44557506-44558892
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Data sourse: ENCSR000BLD, ENCSR000BTU, GSE67783, GSE86191, GSE98367, GSE206145, GSE206145-NatGen2015, GSE120943, GSE25021
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Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Monocytes, Ishikawa, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"14_ReprPCWk": 35%,
"15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXA1, SUZ12, ATF3, ZFP64, THAP1, RUNX3, PAX5, BACH2, JMJD1C, ESR1, OCA2, CTCF, TCF12, LMO1, E2F6, IRF4, TFAP2C, EED, POU2F2, CHD8, BRD1, MYCN, ZBTB48, ZSCAN5A, ERG2, ERG, PBX1, ASCL1, OGG1, MYC, GRHL3, PROX1, GABPA, STAT3, KMT2A, EZH2, GABPB1, SPI1, ZNF490, NCOA2, RUNX1, BCL6, EZH2phosphoT487, ZFX, TET2, CBX8, ERG3, TRIM22, NOTCH1, TAF15, ARNT, MED1, TEAD3, ZNF264, MYB, SCRT2, ZNF41, USF1, HNRNPLL, TCF3, SMC3, STAG1, TRP47, MEF2B, FOXA2, TBL1X, EBF1, CREM, SS18, WT1, CDK9, YY1, RELA, BRG1, MCM3, SP140, ZIC2, ZFP36, TCF4, HIF1A, MAX, SPIB, ZNF143, NRIP1, CBX2, PLAG1, TP53, BHLHE40, AR, HSF1, SCRT1, BRD4, MAZ
- Target gene symbol (double-evidenced CRMs): TSPEAR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 751
- Number of somatic mutations (non-coding): 5
- Related genes and loops