- Basic information
- CohesinDB ID: CDBP00421041
- Locus: chr21-44571827-44575918
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, GSE116868, GSE105028, GSE121355, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE120943, GSE112028, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE126990, GSE38411
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Cell type: Liver, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, K-562, BCBL-1, DKO, H1-hESC, Monocytes, MB157, RT-112, HeLa-Tet-On, Macrophage, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 13% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.767
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 26%,
"9_Het": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, HMG20A, NME2, MEIS2, FOXA1, PBX2, RXRB, ZFHX2, ATF3, ZBTB5, PRDM1, CBFB, MXD4, MITF, TEAD1, TRIM28, LMO2, ESR1, OCA2, USF2, CTCF, TCF12, JUN, MNT, GATA6, SOX5, DPF2, TRIM24, ZNF410, ZNF280A, FOXA3, RBPJ, TFAP2C, ZSCAN5D, ZNF263, MYCN, CTBP1, ZBTB48, GATAD1, SAP130, ERG2, ERG, OGG1, MYC, EZH1, RFX1, HOMEZ, GRHL3, STAT3, XRCC5, DNMT3B, VDR, NR3C1, CEBPB, HNRNPL, CREB1, EZH2, GRHL2, GABPB1, SPI1, TFE3, ZNF644, MXD3, FLI1, ZGPAT, HCFC1R1, NFIL3, RUNX1, BCL6, CEBPA, HDAC1, SOX13, ZFX, SMAD3, TET2, ERG3, ZNF549, CREBBP, RARA, RUNX2, ARNT, PBX4, BACH1, NRF1, ZNF48, SMAD4, FOS, HMGXB4, SMARCB1, TEAD3, PIAS1, ZNF3, L3MBTL2, SETDB1, USF1, BCL11A, IKZF5, ASH2L, ZNF605, AATF, STAG1, SKI, TRP47, CBFA2T2, FOXA2, SS18, WT1, CDK9, KDM1A, RELA, TARDBP, JUNB, MCM3, SP140, HIF1A, GATA3, MAX, NRIP1, ZNF143, PLAG1, CEBPG, NCOA3, NR2F1, ZBTB6, PKNOX1, ELF3, BHLHE40, AR, NFKBIZ, RXR, EGLN2, HEXIM1, ZNF280D, HSF1, ZBTB26, BRD4, JUND, CUX1, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): PCBP3,TSPEAR,ADARB1
- Function elements
- Human SNPs: Leukocyte_telomere_length
- Number of somatic mutations (coding): 2315
- Number of somatic mutations (non-coding): 372
- Related genes and loops