- Basic information
- CohesinDB ID: CDBP00421046
- Locus: chr21-44589306-44594970
-
Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, GSE131606, GSE25021, ENCSR000EDW, ENCSR917QNE, ENCSR000BTU, GSE143937, GSE67783, GSE86191, GSE115250, GSE138405, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, GSE116344, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE55407, ENCSR167MTG, GSE110061, GSE111913, ENCSR054FKH, ENCSR153HNT
-
Cell type: RH4, Liver, TC-32, RPE, Fibroblast, Ishikawa, K-562, DKO, H1-hESC, MB157, RT-112, HeLa-Tet-On, THP-1, Macrophage, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.789
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"14_ReprPCWk": 33%,
"15_Quies": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: RUNX1, GLIS1, NCOA2, TRP47, PPARG, FOXA2, MYCN, POU5F1, SS18, ZFX, XBP1, ZBTB48, WT1, FOXA1, TET2, PBX2, SP4, HOXB13, UBTF, KDM1A, ERG, RELA, IRF2, OGG1, ATF3, MYC, EZH1, BRG1, SP140, ZIC2, HIF1A, GRHL3, ZNF48, STAT3, ETV6, XRCC5, TP63, DNMT3B, ARNTL, TEAD3, ZMYM3, NR2F1, ESR1, GABPB1, CTCF, RXR, RBM25, ZNF146, ZBTB26, BRD4, BCOR, MAZ, AATF, SMC3
- Target gene symbol (double-evidenced CRMs): PCBP3,ADARB1,TSPEAR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 2604
- Number of somatic mutations (non-coding): 41
- Related genes and loops