- Basic information
- CohesinDB ID: CDBP00421047
- Locus: chr21-44596133-44596721
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Data sourse: ENCSR000BTU, GSE67783, GSE86191, GSE111913, ENCSR153HNT, GSE68388, GSE25021
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Cell type: MCF-7, HCT-116, Ishikawa, RT-112, K-562, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"14_ReprPCWk": 43%,
"15_Quies": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, CBX5, HMG20A, SOX2, MEIS2, XBP1, FOXA1, HLF, SUZ12, RBFOX2, PBX2, RXRB, UBTF, KDM3A, TFAP4, HDGF, LYL1, ZNF90, ATF3, THRB, NFIC, CTCFL, ATF4, CBFB, MXD4, MECOM, SMARCE1, TP63, HDAC3, TEAD1, TRIM28, KLF6, ETV1, NFE2L2, RCOR2, ESR1, OCA2, TP73, LMO2, HDAC8, CTCF, TCF12, JUN, EP300, KLF1, E4F1, MNT, SOX5, PYGO2, DPF2, DMAP1, E2F6, TRIM24, CREB3, E2F4, SOX6, ZNF528, TEAD4, FOXA3, KMT2B, ZNF175, GTF2F1, GATAD2A, RBPJ, TFAP2C, EED, MLX, EHMT2, POU2F2, CHD8, MYCN, ZNF263, POU5F1, ID3, CTBP1, MTA2, ZBTB48, ZSCAN5A, STAT1, HINFP, MLLT3, GATAD1, SAP130, NBN, ARID3A, TBP, HNF4G, ERG, OGG1, SMARCC2, MYC, EZH1, SMARCA4, HOMEZ, RAD21, ARID1B, GRHL3, RXRA, NKX2-1, FOXK2, MCRS1, GABPA, STAT3, XRCC5, ZNF614, MIER3, DNMT3B, HNRNPH1, NR2F6, NFE2, LEF1, NR3C1, CEBPB, SRSF3, ESRRA, NFRKB, ARNTL, KMT2A, CREB1, EZH2, TBL1XR1, GRHL2, ZNF652, NFE2L1, GABPB1, ZHX2, SPI1, TFE3, MIXL1, IRF1, HDAC2, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, ZGPAT, ZNF490, NFIL3, EP400, ZNF316, ATF1, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, LDB1, HDAC1, SOX13, ZFX, SMAD3, TET2, SP5, ZMIZ1, SMARCC1, NSD2, PRDM10, RARA, ZNF384, CREBBP, ZNF184, ARNT, NRF1, TFDP1, PBX4, ZNF48, SMAD4, ZEB2, CBFA2T3, FOXM1, NR2C1, ETV6, HMGXB4, CDK8, ZNF584, TEAD3, PML, KDM6B, MYB, CEBPD, ZMYM3, TERF1, ZEB1, TAF7, ZNF3, KLF9, NCOA1, L3MBTL2, SETDB1, STAT5A, KLF16, SP1, BCL11A, NR4A1, HNF4A, IKZF5, REST, ZBTB7A, CCNT2, ATF7, ASH2L, HNRNPLL, AFF1, TCF3, BCOR, THRA, AATF, SMC3, STAG1, PTTG1, NFATC3, TRP47, CBFA2T2, KLF13, PPARG, FOXA2, MTA3, RBBP5, CBX3, SS18, AGO1, ZNF600, MIER2, MEIS1, WT1, CREM, ZSCAN16, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, ZNF589, TARDBP, NEUROD1, JUNB, BRG1, SP140, ZIC2, HIF1A, ZFP36, MGA, TAL1, MAX, NRIP1, GATA1, ZNF143, PLAG1, CEBPG, ZNF592, NCOA3, GFI1B, NR2F2, ZNF512, NR2F1, TP53, PKNOX1, PHF5A, ELF3, KAT8, NFKBIZ, ARID4B, BHLHE40, AR, PTRF, ZBTB40, RXR, ZBTB42, ZBTB26, HSF1, RNF2, BRD4, ILF3, JUND, NCOR1, MYNN, MAZ, RCOR1, IRF9, MEF2D, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): ADARB1,PCBP3,TSPEAR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 8
- Number of somatic mutations (non-coding): 2
- Related genes and loops