- Basic information
- CohesinDB ID: CDBP00421059
- Locus: chr21-44648535-44651485
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Data sourse: ENCSR000BLD, GSE67783, GSE86191, GSE116868, GSE105028, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, GSE68388, GSE111537
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Cell type: RPE, H1-hESC, Fibroblast, HCT-116, MB157, K-562, OCI-AML-3, HSPC, HuCC-T1, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 38%,
"14_ReprPCWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, SOX2, XBP1, ZNF101, FOXA1, KDM4B, SUZ12, PBX2, ZNF28, ZFHX2, LYL1, ATF3, THAP1, CHD7, CBFB, MECOM, JMJD1C, TRIM28, LMO2, ESR1, OCA2, USF2, CTCF, JUN, MNT, E2F6, E2F4, RAD51, ZNF528, TFAP2C, EED, POU2F2, ZNF425, BRD1, MYCN, ZNF263, TOP2A, ZBTB48, ZSCAN5A, ERG2, SP4, ERG, PBX1, ASCL1, OGG1, MYC, ONECUT1, SMARCA4, RAD21, GRHL3, STAT3, XRCC5, PRDM14, DNMT3B, ARNTL, CEBPB, CREB1, EZH2, GRHL2, GABPB1, FLI1, NCOA2, MYF5, RUNX1, SMC1A, CEBPA, EZH2phosphoT487, ZFX, TET2, ERG3, CREBBP, RARA, TAF15, ARNT, SOX11, ZNF48, NCAPH2, CHD1, CDK8, SMARCB1, FOS, KDM6B, MYB, ZNF3, L3MBTL2, USF1, BCL11A, REST, HNRNPLL, AATF, SMC3, STAG1, TRP47, CBFA2T2, FOXA2, TBL1X, AGO1, SS18, WT1, HOXB13, KDM1A, YY1, RELA, NEUROD1, BRG1, MCM3, SP140, ZIC2, HIF1A, OTX2, MAX, PLAG1, CEBPG, NCOA3, NR2F1, KDM5B, TP53, ZNF334, MYOD1, AR, RXR, EGLN2, HEXIM1, TFIIIC, HSF1, ZBTB26, BRD4, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): TSPEAR,PTTG1IP,ITGB2,ADARB1,PCBP3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 129
- Number of somatic mutations (non-coding): 43
- Related genes and loops
- Related gene:
ENSG00000175894,
ENSG00000183255,
ENSG00000160255,
ENSG00000197381,
ENSG00000183570,
- Related loop:
chr21:22525000-22550000~~chr21:44650000-44675000,
chr21:27500000-27525000~~chr21:44625000-44650000,
chr21:27500000-27525000~~chr21:44650000-44675000,
chr21:44475000-44500000~~chr21:44650000-44675000,
chr21:44625000-44650000~~chr21:44725000-44750000,
chr21:44625000-44650000~~chr21:45725000-45750000,
chr21:44650000-44675000~~chr21:44875000-44900000,
chr21:44650000-44675000~~chr21:45200000-45225000,
chr21:44650000-44675000~~chr21:45325000-45350000,