- Basic information
- CohesinDB ID: CDBP00421062
- Locus: chr21-44653790-44655119
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Data sourse: GSE116344, GSE67783, GSE86191
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Cell type: RH4, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SA1,Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 36%,
"14_ReprPCWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, ZNF496, HMG20A, PBX2, RXRB, KDM3A, ZNF90, ATF3, CBFB, MXD4, MITF, TEAD1, KLF6, SNAI2, LMO2, ESR1, CTCF, JUN, TCF12, MNT, SOX5, E2F6, E2F4, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, TFAP2C, MLX, GLIS1, POU2F2, MYCN, POU5F1, CTBP1, ZBTB48, GATAD1, SAP130, PBX1, ASCL1, OGG1, MYC, SMARCA4, HOMEZ, GRHL3, GABPA, STAT3, PRDM14, MIER3, DNMT3B, NR2F6, STAT5B, CREB1, EZH2, GABPB1, TFE3, MXD3, FLI1, NR2C2, ETV5, RUNX1, THAP11, CBX1, SMC1A, CEBPA, EZH2phosphoT487, SOX13, ZFX, ERG3, RARA, ARNT, TFDP1, ZNF48, SMAD4, NR2C1, CHD1, TEAD3, MYB, L3MBTL2, SETDB1, USF1, SP1, REST, TCF3, AATF, SMC3, STAG1, NFATC3, TRP47, CBX3, FOXA2, E2F8, WT1, CDK9, ZNF580, YY1, RELA, SP140, ZIC2, HIF1A, MGA, TAL1, MAX, MAF1, NR2F1, TP53, MYOD1, ELF3, KAT8, TBX21, BHLHE40, NFKBIZ, RXR, ZBTB42, HEXIM1, ZBTB26, RNF2, HSF1, BRD4, JUND, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): TSPEAR,PTTG1IP,ADARB1,ITGB2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 426
- Number of somatic mutations (non-coding): 108
- Related genes and loops
- Related gene:
ENSG00000175894,
ENSG00000183255,
ENSG00000160255,
ENSG00000197381,
- Related loop:
chr21:22525000-22550000~~chr21:44650000-44675000,
chr21:27500000-27525000~~chr21:44625000-44650000,
chr21:27500000-27525000~~chr21:44650000-44675000,
chr21:44475000-44500000~~chr21:44650000-44675000,
chr21:44625000-44650000~~chr21:44725000-44750000,
chr21:44625000-44650000~~chr21:45725000-45750000,
chr21:44650000-44675000~~chr21:44875000-44900000,
chr21:44650000-44675000~~chr21:45200000-45225000,
chr21:44650000-44675000~~chr21:45325000-45350000,