- Basic information
- CohesinDB ID: CDBP00421068
- Locus: chr21-44666337-44666984
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Data sourse: GSE206145, GSE116868, ENCSR153HNT, GSE86191
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Cell type: K-562, RPE, HCT-116, MB157
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 43%,
"14_ReprPCWk": 37%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, TRP47, POU2F2, PGR, POU5F1, MYCN, TOP2A, CRY1, ZFX, EZH2phosphoT487, XBP1, ZBTB48, SMAD3, FOXA1, HOXB13, ERG, YY1, RELA, TFAP4, ASCL1, OGG1, AHR, MYC, SP140, ARNT, HIF1A, GRHL3, PBX4, CBFB, GABPA, STAT3, MAX, PAX5, ZNF143, FOS, MITF, NR3C1, NCOA3, TEAD1, NR2F1, PIAS1, EZH2, ESR1, GRHL2, USF2, MYOD1, CTCF, JUN, BAF155, AR, RXR, GATA2, TRIM24, EGLN2, HSF1, RAD51, BRD4, E2F1, MAZ, AATF, TFAP2C
- Target gene symbol (double-evidenced CRMs): TSPEAR,ADARB1,ITGB2,PTTG1IP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 464
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000175894,
ENSG00000183255,
ENSG00000160255,
ENSG00000197381,
- Related loop:
chr21:22525000-22550000~~chr21:44650000-44675000,
chr21:27500000-27525000~~chr21:44650000-44675000,
chr21:44475000-44500000~~chr21:44650000-44675000,
chr21:44650000-44675000~~chr21:44875000-44900000,
chr21:44650000-44675000~~chr21:45200000-45225000,
chr21:44650000-44675000~~chr21:45325000-45350000,