- Basic information
- CohesinDB ID: CDBP00421077
- Locus: chr21-44694749-44695961
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Data sourse: GSE86191, GSE111913, GSE67783, GSE72082
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Cell type: RT-112, HCT-116, HSPC, Hep-G2
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 46%,
"13_ReprPC": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, TRP47, POU2F2, CHD8, BRD1, CBFA2T2, MYCN, EZH2phosphoT487, TOP2A, ID3, ZFX, SS18, XBP1, POU5F1, ZBTB48, WT1, ZSCAN5A, FOXA1, SMAD3, TET2, SAP130, SUZ12, ERG, YY1, RELA, RARA, KDM1A, AHR, MYC, BRG1, SMARCA4, ZBTB5, RAD21, SP140, GRHL3, ARNT, PRDM1, MCM3, PRDM9, MECOM, NRIP1, FOS, ZNF143, MITF, NR2F6, ARNTL, NCOA3, TEAD3, TERF1, CEBPD, CREB1, NR2F1, ZMYM3, EZH2, RCOR2, ESR1, ZNF334, GABPB1, CTCF, ELF3, USF1, BCL11A, SPI1, AR, RBM25, ATF7, FLI1, HNRNPLL, JUND, MAZ, HCFC1R1, AATF, SMC3, STAG1, TFAP2C, EED
- Target gene symbol (double-evidenced CRMs): TSPEAR,HSF2BP,DNMT3L
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 24
- Number of somatic mutations (non-coding): 8
- Related genes and loops
- Related gene:
ENSG00000160207,
ENSG00000142182,
ENSG00000175894,
- Related loop:
chr21:43575000-43600000~~chr21:44675000-44700000,
chr21:44175000-44200000~~chr21:44700000-44725000,
chr21:44250000-44275000~~chr21:44675000-44700000,
chr21:44325000-44350000~~chr21:44700000-44725000,
chr21:44500000-44525000~~chr21:44700000-44725000,
chr21:44575000-44600000~~chr21:44675000-44700000,
chr21:44700000-44725000~~chr21:44925000-44950000,