Deatailed information for cohesin site CDBP00421081

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  • Basic information
  • CohesinDB ID: CDBP00421081
  • Locus: chr21-44701494-44705032
  • Data sourse: ENCSR000BLD, ENCSR167MTG, ENCSR338DUC, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE111913, ENCSR000BLS, GSE105028, GSE206145-NatGen2015, ENCSR054FKH, GSE206145, ENCSR153HNT, GSE25021, GSE64758, GSE115602
  • Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Hep-G2, RT-112, K-562, HSPC, H9-hESC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 5% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.889
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 80% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): False
  • Chromatin annotation: "13_ReprPC": 40%, "14_ReprPCWk": 22%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: NFIA, FOSL1, TRIM25, PGR, HMG20A, FOXA1, SUZ12, RBFOX2, RXRB, ZFHX2, KDM3A, TFAP4, ATF3, THRB, ZFP64, THAP1, CHD7, RUNX3, ZNF322, CBFB, MXD4, PAX5, TP63, ZNF736, KLF5, TEAD1, TRIM28, KLF6, RBM39, ETV1, KLF10, RCOR2, ESR1, SAP30, LMO2, USF2, CTCF, JUN, TCF12, EP300, KLF1, MNT, SOX5, RYBP, PAX8, DMAP1, E2F6, ZNF512B, E2F1, TEAD4, FOXA3, ZNF175, GATAD2A, PDX1, TFAP2C, MLX, RBPJ, GLIS1, JARID2, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, POU5F1, ZNF263, NANOG, CTBP1, ZNF317, ZBTB17, ZBTB48, DUX4, STAT1, ZSCAN5A, GATAD1, SAP130, DDX5, ERG2, ARID3A, ZNF485, HNF4G, ERG, ASCL1, OGG1, ETS1, MYC, SMARCA4, EOMES, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, PRDM14, MIER3, RCOR1, NR2F6, DNMT3B, HNRNPH1, NR3C1, ESRRA, CEBPB, HNRNPL, CREB1, EZH2, TBL1XR1, BMPR1A, GRHL2, ZNF652, TRPS1, GABPB1, ZHX2, TFE3, MIXL1, HBP1, KLF17, PCBP1, HDAC2, GATA2, ZNF644, MXD3, DRAP1, ZGPAT, NR2C2, RELB, NFIL3, NCOA2, MYF5, PTBP1, ETV5, RUNX1, THAP11, BCL6, CBX1, CEBPA, EZH2phosphoT487, SIRT6, SMC1A, SOX13, ZFX, NKX2-2, SIN3A, SMAD3, TET2, ERG3, SP5, SMARCC1, PRDM10, RARA, NFYC, CREBBP, RUNX2, ARNT, BACH1, ZNF48, SMAD4, NCAPH2, FOS, CHD1, HMGXB4, MED1, TEAD3, CEBPD, KDM6B, ZMYM3, MBD1, MAFK, USF1, TFAP2A, SP1, HNF4A, BCL11A, NIPBL, IKZF5, ZBTB7A, ASH2L, HNRNPLL, CTBP2, BCOR, FOXP1, AATF, SMC3, NCOR2, STAG1, NFATC3, SKI, TRP47, CBFA2T2, PPARG, FOXA2, AGO1, CREM, SS18, MIER2, WT1, MAFF, TCF7, CDK9, ZNF580, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, BRG1, SP140, ZIC2, HIF1A, PCGF1, GATA3, MAF1, MAX, NRIP1, ZNF143, GATA1, PLAG1, CEBPG, NCOA3, NR2F2, NEUROG2, NR2F1, KDM5B, TP53, PKNOX1, ZBTB6, EGR2, ELF3, PHF5A, KAT8, ARID4B, NFKBIZ, BHLHE40, AR, RXR, EGLN2, ZBTB42, HEXIM1, EGR1, TFIIIC, ZBTB26, RNF2, HSF1, BRD4, JUND, NCOR1, CLOCK, CUX1, MAZ, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): GATD3A,PFKL,ITGB2,TRPM2,FAM207A,ITGB2-AS1,CFAP410,TSPEAR
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 192
  • Number of somatic mutations (non-coding): 64
  • Related genes and loops
  • Related gene: ENSG00000160221, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000160255, ENSG00000227039, ENSG00000160256,
  • Related loop: chr21:43575000-43600000~~chr21:44675000-44700000, chr21:44175000-44200000~~chr21:44700000-44725000, chr21:44250000-44275000~~chr21:44675000-44700000, chr21:44325000-44350000~~chr21:44700000-44725000, chr21:44500000-44525000~~chr21:44700000-44725000, chr21:44575000-44600000~~chr21:44675000-44700000, chr21:44700000-44725000~~chr21:44925000-44950000, chr21:44707178-44708406~~chr21:44792109-44794449,
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