Deatailed information for cohesin site CDBP00421082

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  • Basic information
  • CohesinDB ID: CDBP00421082
  • Locus: chr21-44705399-44713548
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, ENCSR760NPX, ENCSR000BLY, ENCSR404BPV, GSE105028, ENCSR000ECS, GSE131606, GSE108869, GSE25021, ENCSR000BUC, GSE115602, GSE93080, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE112028, ENCSR703TNG, GSE106870, GSE116344, ENCSR895JMI, GSE118494, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR000BTQ, ENCSR853VWZ, ENCSR956LGB, GSE111913, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR748MVX, GSE64758
  • Cell type: RH4, CVI-hiPSC, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, HeLa-S3, IMR-90, K-562, GM18486, DKO, H1-hESC, Monocytes, GM12878, GM12891, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 23% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.644
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 80% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): False
  • Chromatin annotation: "13_ReprPC": 34%, "12_EnhBiv": 27%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: MBD3, FOXO1, TRIM25, CBX5, PGR, FOSL1, SOX2, XBP1, KDM4B, FOXA1, HLF, SUZ12, RING1B, MLL4, ZFHX2, TFAP4, ZNF90, ATF3, NFIC, BMI1, CTCFL, CHD7, CBFB, ZNF189, SMARCE1, TP63, ZNF467, JMJD1C, KLF5, TEAD1, TRIM28, RBM39, SNAI2, SAP30, ESR1, OCA2, USF2, CTCF, TCF12, JUN, EP300, BAF155, MNT, SOX5, RYBP, PAX8, SOX4, E2F6, TRIM24, PRKDC, E2F1, NR5A2, TEAD4, TFAP2C, EED, RBPJ, JARID2, GLIS1, POU2F2, NANOG, BRD1, CHD8, MYCN, POU5F1, ZNF263, RUNX1T1, ZBTB48, ZSCAN5A, ERG2, SP4, ERG, ASCL1, OGG1, ETS1, MYC, SMARCA4, KDM4A, RAD21, GRHL3, PROX1, NKX2-1, GABPA, STAT3, NKX3-1, PRDM14, NFE2, NR2F6, VDR, NR3C1, ESRRA, SRSF3, ZNF750, CEBPB, KMT2A, CREB1, EZH2, GRHL2, GABPB1, PHF8, ZHX2, SPI1, PCBP1, HDAC2, GATA2, MXD3, FLI1, MXI1, HCFC1R1, RUNX1, AHRR, SMC1A, BCL6, CBX1, EZH2phosphoT487, SIRT6, CRY1, SIN3A, ZFX, NKX2-2, AFF4, SMAD3, TET2, ERG3, ZNF770, SMARCC1, CREBBP, RARA, TAF15, RUNX2, SMAD2, GATA4, CDK6, NRF1, BACH1, ARNT, ZNF48, PRDM9, SMAD4, MAFB, NCAPH2, CHD1, FOS, MED1, GMEB1, ZEB1, TEAD3, KDM6B, PML, PIAS1, SUPT16H, ZNF3, KLF9, USF1, BCL11A, SP1, NIPBL, TFAP2A, HNF4A, REST, ZBTB7A, ASH2L, HNRNPLL, CTBP2, PCGF2, BCOR, MBD2, FOXP1, AATF, SMC3, STAG1, NFATC3, TRP47, CBFA2T2, SAFB, FOXA2, AGO1, RBBP5, ZNF207, SS18, CBX3, ZNF600, WT1, ZBTB33, CDK9, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, BRG1, SP140, ZIC2, HIF1A, PCGF1, GATA3, MAF1, MAX, NRIP1, ZNF143, MTA1, GATA1, SPIB, CBX2, PLAG1, KLF4, TLE3, CEBPG, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, ZNF334, EGR2, RBM14, T, AR, TAF1, RXR, EGLN2, HEXIM1, EGR1, TFIIIC, HSF1, RNF2, MYNN, BRD4, NCOR1, ZBTB26, MAZ, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): TRPM2,ITGB2-AS1,PFKL,CFAP410,FAM207A,UBE2G2,GATD3A,TSPEAR,ITGB2
  • Function elements
  • Human SNPs: Corticobasal_degeneration
  • Number of somatic mutations (coding): 149
  • Number of somatic mutations (non-coding): 29
  • Related genes and loops
  • Related gene: ENSG00000160221, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000160255, ENSG00000227039, ENSG00000160256,
  • Related loop: chr21:44175000-44200000~~chr21:44700000-44725000, chr21:44325000-44350000~~chr21:44700000-44725000, chr21:44500000-44525000~~chr21:44700000-44725000, chr21:44509197-44511724~~chr21:44717965-44719686, chr21:44509213-44512100~~chr21:44718108-44719341, chr21:44509225-44511899~~chr21:44717741-44719707, chr21:44509481-44512016~~chr21:44717736-44719579, chr21:44509926-44511467~~chr21:44718171-44719367, chr21:44700000-44725000~~chr21:44925000-44950000, chr21:44707178-44708406~~chr21:44792109-44794449,
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