- Basic information
- CohesinDB ID: CDBP00421083
- Locus: chr21-44716685-44716835
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Data sourse: GSE120943, GSE98367
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Cell type: Monocytes, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"14_ReprPCWk": 76%,
"13_ReprPC": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: SMARCA2, SOX2, XBP1, FOXA1, SUZ12, RXRB, NFIC, CHD7, ZSCAN4, TEAD1, TRIM28, ESR1, CTCF, TCF12, BAF155, E2F6, TEAD4, FOXA3, TFAP2C, RBPJ, JARID2, POU2F2, CHD8, ZSCAN5D, MYCN, ZNF263, TOP2A, POU5F1, RUNX1T1, ZBTB48, ZSCAN5A, DDX5, SAP130, TBP, ERG, ZNF341, HOMEZ, RAD21, GABPA, STAT3, XRCC5, HNRNPH1, NR2F6, NR3C1, CEBPB, SRSF3, EZH2, GRHL2, GABPB1, MIXL1, MXD3, SIX2, FLI1, DRAP1, MRTFB, THAP11, SMC1A, ZFX, POU4F2, SMAD3, SMARCC1, TWIST1, ZBTB2, RARA, ARNT, ATF2, ZNF48, ETV6, HMGXB4, TEAD3, PIAS1, C11orf30, TBX5, MAFK, BCL11A, REST, ZBTB7A, ASH2L, BCOR, FOXP1, SMC3, NCOR2, STAG1, CHD2, MAFF, WT1, HOXB13, ZNF580, YY1, RELA, SP140, HIF1A, MAX, ZNF143, TLE3, KDM5B, TP53, ELF3, AR, ZBTB26, BRD4, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): GATD3A,TSPEAR,FAM207A,PFKL,CFAP410,ITGB2,TRPM2,ITGB2-AS1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 1
- Related genes and loops
- Related gene:
ENSG00000160221,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000175894,
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
- Related loop:
chr21:44175000-44200000~~chr21:44700000-44725000,
chr21:44325000-44350000~~chr21:44700000-44725000,
chr21:44500000-44525000~~chr21:44700000-44725000,
chr21:44509197-44511724~~chr21:44717965-44719686,
chr21:44509213-44512100~~chr21:44718108-44719341,
chr21:44509225-44511899~~chr21:44717741-44719707,
chr21:44509481-44512016~~chr21:44717736-44719579,
chr21:44509926-44511467~~chr21:44718171-44719367,
chr21:44700000-44725000~~chr21:44925000-44950000,