- Basic information
- CohesinDB ID: CDBP00421084
- Locus: chr21-44718430-44719031
-
Data sourse: ENCSR000BLD, GSE72082, ENCSR000BLY, GSE105028, GSE131606, GSE25021, ENCSR000EDW, ENCSR000BTU, GSE93080, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE152721, GSE112028, GSE116344, GSE145327, GSE106870, ENCSR000EEG, ENCSR338DUC, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, ENCSR000BTQ, ENCSR167MTG, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893
-
Cell type: RH4, CVB-hiPSC, CVI-hiPSC, HuCC-T1, H9-hESC, RPE, GM2630, Ishikawa, K-562, DKO, H1-hESC, GM12878, GM2588, SK-N-SH, HeLa-Tet-On, HAP1, GM19099, HUES64, MCF-7, HCT-116, Hep-G2, GM19238, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 13% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.744
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"14_ReprPCWk": 45%,
"13_ReprPC": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: SMARCA2, SOX2, XBP1, FOXA1, SUZ12, RXRB, NFIC, CHD7, ZSCAN4, TEAD1, TRIM28, ESR1, CTCF, TCF12, BAF155, E2F6, TEAD4, FOXA3, TFAP2C, RBPJ, JARID2, POU2F2, CHD8, ZSCAN5D, MYCN, ZNF263, TOP2A, POU5F1, RUNX1T1, ZBTB48, ZSCAN5A, DDX5, SAP130, TBP, ERG, ZNF341, HOMEZ, RAD21, GABPA, STAT3, XRCC5, HNRNPH1, NR2F6, NR3C1, CEBPB, SRSF3, EZH2, GRHL2, GABPB1, MIXL1, MXD3, SIX2, FLI1, DRAP1, MRTFB, THAP11, SMC1A, ZFX, POU4F2, SMAD3, SMARCC1, TWIST1, ZBTB2, RARA, ARNT, ATF2, ZNF48, ETV6, HMGXB4, TEAD3, PIAS1, C11orf30, TBX5, MAFK, BCL11A, REST, ZBTB7A, ASH2L, BCOR, FOXP1, SMC3, NCOR2, STAG1, CHD2, MAFF, WT1, HOXB13, ZNF580, YY1, RELA, SP140, HIF1A, MAX, ZNF143, TLE3, KDM5B, TP53, ELF3, AR, ZBTB26, BRD4, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): GATD3A,PFKL,TSPEAR,CFAP410,TRPM2,ITGB2-AS1,FAM207A,ITGB2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000160221,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000175894,
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
- Related loop:
chr21:44175000-44200000~~chr21:44700000-44725000,
chr21:44325000-44350000~~chr21:44700000-44725000,
chr21:44500000-44525000~~chr21:44700000-44725000,
chr21:44509197-44511724~~chr21:44717965-44719686,
chr21:44509213-44512100~~chr21:44718108-44719341,
chr21:44509225-44511899~~chr21:44717741-44719707,
chr21:44509481-44512016~~chr21:44717736-44719579,
chr21:44509926-44511467~~chr21:44718171-44719367,
chr21:44700000-44725000~~chr21:44925000-44950000,