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Basic information

CohesinDB ID: CDBP00421088

Locus: chr21-44724719-44725397

Data sourse: GSE111913, GSE67783, GSE86191

Cell type: RT-112, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 80% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 52%, "13_ReprPC": 38%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, SUZ12, RING1B, MLL4, ZFHX2, LYL1, BMI1, ATF3, HNRNPUL1, CTCFL, CHD7, THAP1, CBFB, ZNF189, TP63, MITF, JMJD1C, KLF5, TRIM28, LMO2, ESR1, MLL, TP73, OCA2, CTCF, EP300, ARID5B, RYBP, DPF2, E2F6, TRIM24, KMT2B, PDX1, TFAP2C, EED, JARID2, NANOG, CHD8, BRD1, POU2F2, MYCN, POU5F1, ZNF263, KDM4C, ZBTB17, ZBTB48, DDX5, ERG2, ERG, PBX1, OGG1, MYC, SMARCA4, RFX1, KDM4A, RAD21, GRHL3, PROX1, GABPA, STAT3, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, CEBPB, KMT2A, EZH2, SPI1, HDAC2, GATAD2B, MXD3, SIX2, FLI1, SMARCA5, RUNX1, CEBPA, EZH2phosphoT487, NKX2-2, SIRT6, ZFX, ERG3, CBX8, SMARCC1, RARA, PRPF4, NOTCH1, TAF15, MAFB, NCAPH2, CHD1, CDK8, MYB, SCRT2, SETDB1, STAT5A, BCL11A, TFAP2A, POU2F3, ASH2L, CTBP2, BCOR, TCF3, AATF, STAG1, TRP47, CBFA2T2, MEF2B, FOXA2, RBBP5, EBF1, WT1, KDM1A, YY1, RELA, TARDBP, BRG1, SP140, HIF1A, PCGF1, TAL1, MAX, CBX2, PLAG1, NCOA3, NEUROG2, TCF7L2, KDM5B, TP53, PKNOX1, MED, EGR2, T, BHLHE40, AR, RXR, HEXIM1, TFIIIC, HSF1, RNF2, BRD4, SCRT1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): CFAP410,TRPM2,TSPEAR,ITGB2-AS1,FAM207A,GATD3A,TRAPPC10,PFKL,ITGB2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene: ENSG00000160218, ENSG00000160221, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000160255, ENSG00000227039, ENSG00000160256,

eachgene

Deatailed information for cohesin site CDBP00421088