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Basic information

CohesinDB ID: CDBP00421089

Locus: chr21-44726838-44728488

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 80% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 58%, "13_ReprPC": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, GLIS1, TRP47, CBFA2T2, POU2F2, EZH2phosphoT487, MYCN, TOP2A, ZNF263, ZFX, AFF4, XBP1, ZBTB48, WT1, FOXA1, TET2, ZNF770, SUZ12, ETV5, YY1, RELA, ATF3, MYC, ETS1, SP140, ARNT, RXRA, ZNF48, STAT3, TP63, PRDM14, FOS, DNMT3B, ELF1, TRIM28, NR2F1, EZH2, LMO2, ESR1, GABPB1, CTCF, KLF1, EGR1, HSF1, ZBTB26, BRD4, MAZ, AATF, HCFC1R1, STAG1, AHR

Target gene symbol (double-evidenced CRMs): TSPEAR,PFKL,CFAP410,TRAPPC10,TRPM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 12

Related genes and loops

Related gene: ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

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Deatailed information for cohesin site CDBP00421089