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Basic information

CohesinDB ID: CDBP00421099

Locus: chr21-44748543-44754678

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR404BPV, GSE105028, GSE131606, GSE25021, GSE108869, GSE115602, GSE67783, GSE86191, GSE115250, GSE76893, GSE101921, GSE206145-NatGen2015, ENCSR703TNG, GSE106870, GSE206145, GSE85526, GSE97394, GSE55407, ENCSR000BTQ, GSE110061, GSE129526, GSE111913, ENCSR153HNT, GSE68388

Cell type: CVI-hiPSC, TC-32, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, HeLa-S3, K-562, DKO, H1-hESC, RT-112, THP-1, HUES64, MCF-7, HCT-116, Neurons-H1, HCAEC, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.789

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 82% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 26%, "15_Quies": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, TRIM25, PGR, FOSL1, SOX2, XBP1, KDM4B, FOXA1, SUZ12, MLL4, ZBTB7B, TFAP4, MEN1, ATF3, THAP1, CHD7, WDHD1, ZNF444, CBFB, SMARCE1, TP63, CDX2, JMJD1C, KLF5, ELF1, TRIM28, TEAD1, RBM39, ETV1, KLF6, SNAI2, LMO2, ESR1, OCA2, ZNF217, ZNF573, USF2, CTCF, TCF12, JUN, EP300, BAF155, MNT, SOX9, RYBP, DPF2, PAX8, E2F6, TRIM24, RFX5, RAD51, ZNF512B, E2F1, NR5A2, SMC1, TEAD4, GTF2F1, TFAP2C, JARID2, NANOG, POU2F2, BRD1, ZSCAN5D, MYCN, POU5F1, ZNF263, BRD3, CTBP1, ZBTB48, ZSCAN5A, STAT1, SRF, TBP, ERG, HOXC5, OGG1, ETS1, MYC, SMARCA4, KDM4A, RAD21, FOXP2, GRHL3, PROX1, GABPA, STAT3, APC, NKX3-1, PRDM14, RCOR1, DNMT3B, VDR, ARNTL, ZNF750, NR3C1, SRSF3, ESRRA, HNRNPL, CEBPB, CREB1, EZH2, BMPR1A, GRHL2, TRPS1, GABPB1, SPI1, EHF, IRF1, ZNF257, HDAC2, SSRP1, GATA2, GATAD2B, SIX2, FLI1, HCFC1R1, MRTFB, NCOA2, ETV5, RUNX1, CBX1, SMC1A, CEBPA, CRY1, SIN3A, ZFX, SMAD3, PCBP2, TET2, CBX8, ERG3, ZNF770, SMARCC1, RARA, CREBBP, ZXDC, TAF15, RUNX2, SMAD2, GATA4, ARNT, NFIB, DAXX, NRF1, PBX4, SOX11, FOXM1, CHD1, CDK8, FOS, MED1, ZEB1, TEAD3, SCRT2, PIAS1, ZNF3, USF1, BCL11A, TFAP2A, NIPBL, NR4A1, SP1, REST, ZBTB7A, POU2F3, ZHX1, ASH2L, CTBP2, PHIP, BCOR, FOXP1, TCF3, MBD2, AATF, SMC3, STAG1, STAG2, TRP47, CBFA2T2, FOXA2, AGO1, RBBP5, MTA3, SS18, TBL1X, CBX3, EBF1, WT1, MEF2C, ZBTB33, CDK9, HOXB13, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, NEUROD1, JUNB, BRG1, MCM3, SP140, ZIC2, HIF1A, PCGF1, GATA3, TAL1, MAX, NRIP1, ZNF143, GATA1, MTA1, PLAG1, CBX2, KLF4, ZNF592, TLE3, NCOA3, NR2F2, ZNF512, NR2F1, TCF7L2, KDM5B, TP53, ZNF687, PKNOX1, ZNF334, NFKB1, RBM14, ELF3, AR, TAF1, ZNF579, EGLN2, HEXIM1, EGR1, TFIIIC, HSF1, NCOR1, BRD4, JUND, CLOCK, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): PCBP3,PFKL,CFAP410,AGPAT3,TRPM2,TRAPPC10,TSPEAR

Function elements

Human SNPs: Male-pattern_baldness

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 50

Related genes and loops

Related gene: ENSG00000160216, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421099