- Basic information
- CohesinDB ID: CDBP00421100
- Locus: chr21-44755085-44756295
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Data sourse: GSE72082, ENCSR000EGW, GSE103477, GSE111537, ENCSR000EDW, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE143937, GSE67783, ENCSR000BKV, GSE115250, GSE86191, GSE76893, GSE101921, GSE94872, ENCSR000EEG, ENCSR000BLS, ENCSR167MTG, ENCSR000HPG, GSE155324, ENCSR054FKH, ENCSR153HNT, GSE50893
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Cell type: MDM, GM10847, Liver, TC-32, GM2630, Ishikawa, GM2255, IMR-90, K-562, GM18526, Lymphoblast, GM2588, GM19239, HCT-116, Hep-G2, HUVEC, HCAEC, TC-71, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 10% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.778
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
81% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 49%,
"14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, THAP11, NFIA, ZNF585A, CHD8, SMC1A, CBX3, SS18, STAG2, ZNF317, ERF, SMAD3, ZBTB48, FOXA1, SRF, ZNF654, ZNF770, SMARCC1, ERG, RELA, CREBBP, ZBTB2, NOTCH1, LYL1, JUNB, ETS1, NFIC, ZNF280A, MYC, RAD21, NFIB, NKX2-1, ZEB2, GABPA, TAL1, XRCC5, SMAD4, FOS, ZNF143, TEAD3, NR2F2, TRIM28, ELF1, KLF6, RBM39, LMO2, BMPR1A, SETDB1, ZNF652, GABPB1, CTCF, ELF3, JUN, TCF12, KAT8, SPI1, ZBTB40, GATA2, REST, ZBTB7A, FLI1, HSF1, NCOR1, BRD4, TCF3, SMC1, MRTFB, SMC3, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): CFAP410,TRPM2,PFKL,PCBP3,TSPEAR,UBE2G2,AGPAT3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 17
- Related genes and loops
- Related gene:
ENSG00000160216,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000175894,
ENSG00000184787,
ENSG00000183570,
- Related loop:
chr21:43950000-43975000~~chr21:44750000-44775000,
chr21:44325000-44350000~~chr21:44750000-44775000,
chr21:44350000-44375000~~chr21:44750000-44775000,
chr21:44500000-44525000~~chr21:44750000-44775000,
chr21:44509225-44511899~~chr21:44760944-44762448,
chr21:44750000-44775000~~chr21:45725000-45750000,
chr21:44754736-44756602~~chr21:44792156-44794493,
chr21:5025000-5050000~~chr21:44750000-44775000,
chr21:5100000-5125000~~chr21:44750000-44775000,