Deatailed information for cohesin site CDBP00421101

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  • Basic information
  • CohesinDB ID: CDBP00421101
  • Locus: chr21-44756826-44769032
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR917QNE, GSE115602, ENCSR000BTU, GSE165895, ENCSR000DZP, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE93080, GSE36578, GSE76893, GSE101921, GSE152721, GSE51234, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE38411
  • Cell type: RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, HUVEC, GM19238, BGO3, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 34% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.422
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TES,Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 81% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 27%, "5_TxWk": 25%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, ZNF675, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, PAX5, TEAD1, HDAC8, SOX5, DEK, GATAD2A, JARID2, ZNF263, POU5F1, TOP2A, CTBP1, STAT1, SAP130, ERG, ZBTB8A, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, KLF17, GATA2, MXD3, SIX2, FLI1, DRAP1, HCFC1, MXI1, HCFC1R1, RUNX1, CEBPA, HDAC1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, ZBTB10, ATF2, FOXM1, SP2, PML, PIAS1, SMAD1, EVI1, IKZF5, ARID2, MBD2, NFATC3, CBFA2T2, CBX3, CREM, CHD2, SS18, PAF1, NFATC1, WT1, NEUROD1, ZNF311, BATF, PLAG1, KLF4, ZBTB6, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, SCRT1, FOSL1, XBP1, PBX2, ATF3, RUNX3, CBFB, DPF1, TP63, ZSCAN4, MITF, MAF, MYOG, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, TAF3, MNT, LMO1, DPF2, ZNF423, TFAP2C, RBPJ, ZBTB17, ZBTB48, SRF, PBX1, HOMEZ, RXRA, NKX3-1, PRDM14, HNRNPH1, NR3C1, KMT2A, KLF8, GRHL2, EBF3, SSRP1, THAP11, SOX13, SP3, ARNT, DAXX, NFIB, ZNF48, ZEB2, HMGXB4, TEAD3, KLF9, TBX5, USF1, SP1, BCL11A, TFAP2A, ZNF479, ASH2L, CTBP2, GLIS2, SMC3, STAG1, MLLT1, ZNF394, TRP47, AGO1, MTA3, EBF1, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, TP53, ZNF334, PHF5A, TBX21, EGR1, RNF2, BRD4, JUND, PGR, SOX2, PATZ1, LEO1, TFAP4, BMI1, CHD7, ZNF444, MXD4, ZNF217, ESR1, SAP30, TP73, KLF1, E2F6, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, SP4, HIC1, HNF4G, HOXC5, OGG1, MYC, NKX2-1, GABPA, STAT3, DNMT3B, SRSF3, EZH2, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ZNF554, ETV5, SIN3A, ERG3, RARA, ZNF384, CREBBP, TAF15, SMAD4, CBFA2T3, CDK8, SNRNP70, ZEB1, SREBF2, RBM22, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, ZNF30, ZNF574, RELA, TARDBP, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, MYOD1, T, AR, HEXIM1, DMAP1, AHR, MBD3, FOSL2, RBFOX2, ZNF28, ZFHX2, NFIC, KLF14, KLF5, TRIM28, ETV1, USF2, TCF12, BAF155, EP300, GATA6, ZNF302, RAD51, SMC1, TEAD4, FOXA3, CHD8, BRD1, MYCN, CDK7, ID3, GATAD1, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF750, TFE3, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, IRF2, NOTCH1, RUNX2, GATA4, OSR2, GR, NRF1, PBX4, CHD1, FOS, SUPT5H, MED1, KDM6B, SCRT2, VEZF1, ZNF3, SETDB1, NIPBL, ZBTB7A, TCF3, PAX7, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, GATA1, HAND2, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, ZBTB42, MYNN, MAZ
  • Target gene symbol (double-evidenced CRMs): PFKL,CFAP410,UBE2G2,TRPM2,AGPAT3,PCBP3,TSPEAR
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 1
  • Number of somatic mutations (non-coding): 77
  • Related genes and loops
  • Related gene: ENSG00000160216, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000183570,
  • Related loop: chr21:43950000-43975000~~chr21:44750000-44775000, chr21:44325000-44350000~~chr21:44750000-44775000, chr21:44350000-44375000~~chr21:44750000-44775000, chr21:44500000-44525000~~chr21:44750000-44775000, chr21:44509225-44511899~~chr21:44760944-44762448, chr21:44750000-44775000~~chr21:45725000-45750000, chr21:44754736-44756602~~chr21:44792156-44794493, chr21:5025000-5050000~~chr21:44750000-44775000, chr21:5100000-5125000~~chr21:44750000-44775000,
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