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Basic information

CohesinDB ID: CDBP00421102

Locus: chr21-44769388-44770132

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 52%, "5_TxWk": 45%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, ZNF675, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, PAX5, TEAD1, HDAC8, SOX5, DEK, GATAD2A, JARID2, ZNF263, POU5F1, TOP2A, CTBP1, STAT1, SAP130, ERG, ZBTB8A, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, KLF17, GATA2, MXD3, SIX2, FLI1, DRAP1, HCFC1, MXI1, HCFC1R1, RUNX1, CEBPA, HDAC1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, ZBTB10, ATF2, FOXM1, SP2, PML, PIAS1, SMAD1, EVI1, IKZF5, ARID2, MBD2, NFATC3, CBFA2T2, CBX3, CREM, CHD2, SS18, PAF1, NFATC1, WT1, NEUROD1, ZNF311, BATF, PLAG1, KLF4, ZBTB6, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, SCRT1, FOSL1, XBP1, PBX2, ATF3, RUNX3, CBFB, DPF1, TP63, ZSCAN4, MITF, MAF, MYOG, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, TAF3, MNT, LMO1, DPF2, ZNF423, TFAP2C, RBPJ, ZBTB17, ZBTB48, SRF, PBX1, HOMEZ, RXRA, NKX3-1, PRDM14, HNRNPH1, NR3C1, KMT2A, KLF8, GRHL2, EBF3, SSRP1, THAP11, SOX13, SP3, ARNT, DAXX, NFIB, ZNF48, ZEB2, HMGXB4, TEAD3, KLF9, TBX5, USF1, SP1, BCL11A, TFAP2A, ZNF479, ASH2L, CTBP2, GLIS2, SMC3, STAG1, MLLT1, ZNF394, TRP47, AGO1, MTA3, EBF1, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, TP53, ZNF334, PHF5A, TBX21, EGR1, RNF2, BRD4, JUND, PGR, SOX2, PATZ1, LEO1, TFAP4, BMI1, CHD7, ZNF444, MXD4, ZNF217, ESR1, SAP30, TP73, KLF1, E2F6, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, SP4, HIC1, HNF4G, HOXC5, OGG1, MYC, NKX2-1, GABPA, STAT3, DNMT3B, SRSF3, EZH2, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ZNF554, ETV5, SIN3A, ERG3, RARA, ZNF384, CREBBP, TAF15, SMAD4, CBFA2T3, CDK8, SNRNP70, ZEB1, SREBF2, RBM22, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, ZNF30, ZNF574, RELA, TARDBP, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, MYOD1, T, AR, HEXIM1, DMAP1, AHR, MBD3, FOSL2, RBFOX2, ZNF28, ZFHX2, NFIC, KLF14, KLF5, TRIM28, ETV1, USF2, TCF12, BAF155, EP300, GATA6, ZNF302, RAD51, SMC1, TEAD4, FOXA3, CHD8, BRD1, MYCN, CDK7, ID3, GATAD1, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF750, TFE3, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, IRF2, NOTCH1, RUNX2, GATA4, OSR2, GR, NRF1, PBX4, CHD1, FOS, SUPT5H, MED1, KDM6B, SCRT2, VEZF1, ZNF3, SETDB1, NIPBL, ZBTB7A, TCF3, PAX7, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, GATA1, HAND2, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, ZBTB42, MYNN, MAZ

Target gene symbol (double-evidenced CRMs): PFKL,AGPAT3,TSPEAR,CFAP410,TRPM2,UBE2G2,PCBP3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 1

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000160216, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421102