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Basic information

CohesinDB ID: CDBP00421104

Locus: chr21-44775568-44776159

Data sourse: GSE62063, ENCSR153HNT

Cell type: K-562, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: NIPBL,SA1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 68%, "5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, FOSL1, TRIM25, PGR, SOX2, XBP1, FOXA1, SUZ12, RBFOX2, LEO1, ZBTB7B, TFAP4, HDGF, MEN1, ATF3, NFIC, ZFP64, CHD7, WDHD1, ZNF444, SMARCE1, TP63, ZNF736, MYOG, ELF1, TEAD1, ETV1, ZNF217, ESR1, CTCF, JUN, TCF12, EP300, BAF155, MNT, DPF2, TRIM24, RAD51, ZNF512B, E2F1, TEAD4, GTF2F1, PDX1, TFAP2C, GLIS1, POU2F2, NANOG, CHD8, ZSCAN5D, MYCN, POU5F1, RUNX1T1, KDM4C, BRD1, CTBP1, ZBTB48, DUX4, SRF, HNF4G, ERG, PBX1, ASCL1, OGG1, MYC, SMARCA4, RFX1, RAD21, GRHL3, NKX2-1, GABPA, STAT3, NKX3-1, PRDM14, RCOR1, DNMT3B, VDR, ZNF750, ESRRA, CEBPB, NR3C1, KMT2A, CREB1, EZH2, GRHL2, EBF3, TRPS1, ZHX2, HES1, SPI1, PCBP1, HDAC2, GATA2, GATAD2B, SIX2, FLI1, HCFC1, NCOA2, MYF5, RUNX1, AHRR, CBX1, SMC1A, NKX2-2, EZH2phosphoT487, CRY1, SIN3A, ZFX, SIRT6, POU4F2, TET2, ERG3, TWIST1, SMARCC1, RARA, ZNF384, CREBBP, ZXDC, TAF15, RUNX2, GATA4, GR, ARNT, NFIB, NRF1, ZNF708, PRDM9, ZNF48, FOXM1, MAFB, SUPT5H, FOS, MED1, CSNK2A1, PML, PIAS1, NCOA1, SETDB1, RBM22, MAFK, NIPBL, TFAP2A, GSPT2, HNF4A, REST, ARID1A, ATF7, POU2F3, ASH2L, CTBP2, TCF3, FOXP1, MBD2, AATF, ZNF623, SMC3, STAG1, PAX7, TRP47, ZNF283, FOXA2, TBL1X, PAF1, SS18, ZNF600, WT1, HOXB13, KDM1A, YY1, RELA, TARDBP, NEUROD1, ISL1, SP140, ZIC2, HIF1A, GATA3, MAF1, MAX, TAL1, NRIP1, ZNF143, AGO2, MTA1, HAND2, PLAG1, CBX2, KLF4, ZNF592, TLE3, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, ZNF687, PKNOX1, MED, ZNF334, MYOD1, PHOX2B, AR, PAX3-FOXO1, RXR, YAP1, EGLN2, EGR1, HEXIM1, HSF1, ZBTB26, BRD4, SCRT1, JUND, CLOCK, CUX1, MAZ, TBX2, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): CFAP410,UBE2G2,ADARB1,TRPM2,PTTG1IP,RRP1B,ITGB2-AS1,HSF2BP,FAM207A,TSPEAR,PFKL,TRAPPC10,ITGB2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000160207, ENSG00000160208, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381,

eachgene

Deatailed information for cohesin site CDBP00421104