- Basic information
- CohesinDB ID: CDBP00421107
- Locus: chr21-44784599-44786454
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Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE206145, ENCSR153HNT, GSE83726, GSE116344
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Cell type: MCF-7, RPE, RH4, HCT-116, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: Mau2,SA1,Rad21
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
81% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 51%,
"4_Tx": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, NME2, FOXA1, LEO1, ATF3, ZFP64, ZBTB44, ZNF189, TP63, HDAC3, ZNF467, CDX2, MYOG, TEAD1, ESR1, CTCF, TCF12, BAF155, EP300, ZBTB20, E2F1, GLIS1, NANOG, CHD8, POU2F2, MYCN, TOP2A, ZBTB48, ERG, HOXC5, ZNF585B, ASCL1, MYC, ONECUT1, EZH1, GRHL3, RXRA, NKX2-1, GABPA, STAT3, NKX3-1, VDR, NR3C1, CEBPB, CREB1, FEZF1, ZNF257, HDAC2, GATA2, FLI1, ZNF554, RUNX1, ZFX, PCBP2, TET2, PRDM10, CREBBP, RUNX2, GATA4, OSR2, PBX4, DAXX, ARNT, SUPT5H, MED1, ZXDB, PIAS1, ZNF3, KLF16, RBM22, BCL11A, TFAP2A, GSPT2, HNF4A, ARID1A, ZSCAN31, ASH2L, FOXP1, PRDM6, AATF, SMC3, STAG1, MLLT1, NFATC3, TRP47, CBFA2T2, ZNF283, FOXA2, TBL1X, AGO1, PAF1, WT1, HOXB13, ZNF19, RELA, YY1, NEUROD1, SP140, ZIC2, HIF1A, OTX2, GATA3, ZNF143, AGO2, TLE3, SP7, NCOA3, TCF7L2, TP53, NFKB1, ZNF843, AR, ZBTB42, ZBTB26, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): PTTG1IP,HSF2BP,TSPEAR,ADARB1,CFAP410,UBE2G2,RRP1B,TRPM2,TRAPPC10,PFKL,ITGB2,ITGB2-AS1,FAM207A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 10
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000160207,
ENSG00000160208,
ENSG00000160218,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000175894,
ENSG00000184787,
ENSG00000183255,
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
ENSG00000197381,
- Related loop:
chr21:27500000-27525000~~chr21:44775000-44800000,
chr21:43350000-43375000~~chr21:44775000-44800000,
chr21:43650000-43675000~~chr21:44775000-44800000,
chr21:44075000-44100000~~chr21:44775000-44800000,
chr21:44325000-44350000~~chr21:44775000-44800000,
chr21:44350000-44375000~~chr21:44775000-44800000,
chr21:44475000-44500000~~chr21:44775000-44800000,
chr21:44500000-44525000~~chr21:44775000-44800000,
chr21:44775000-44800000~~chr21:44875000-44900000,
chr21:44775000-44800000~~chr21:44900000-44925000,
chr21:44775000-44800000~~chr21:44925000-44950000,
chr21:44775000-44800000~~chr21:45125000-45150000,
chr21:5100000-5125000~~chr21:44775000-44800000,