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Basic information

CohesinDB ID: CDBP00421113

Locus: chr21-44799103-44805501

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 68% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.222

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "2_TssAFlnk": 23%, "5_TxWk": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, MORC2, PAX5, TEAD1, E2F5, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, ZNF75A, SOX5, ZNF407, E2F4, DEK, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, BRD3, POU5F1, ZNF263, CTBP1, ZMYND11, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, FOXK2, ZNF398, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, RBM34, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, NR2C2, DRAP1, ZNF785, RELB, EP400, RUNX1, CEBPA, NKX2-2, HDAC1, PALB2, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, TFDP1, ELK1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, C11orf30, MBD1, GSPT2, IKZF5, ARID2, AFF1, MBD2, ELL2, ZNF704, HMGB1, ETV4, NFATC3, ZNF207, CBX3, CREM, CHD2, PAF1, SS18, NFATC1, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, MAF1, PLAG1, KLF4, ZFP69B, BCL11B, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, HNRNPK, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, ZNF273, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF423, RBPJ, TFAP2C, MLX, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, NONO, SRF, NBN, ONECUT1, ZNF2, HOMEZ, KDM4A, FOXP2, TSHZ1, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, CCAR2, TBL1XR1, KLF8, GRHL2, ZNF565, EBF3, KDM5A, ZBTB14, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, LDB1, SOX13, AFF4, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, BACH1, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, SP1, NKX2-5, ATF7, ASH2L, PCGF2, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, ZNF19, KLF7, BRG1, ISL1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, FANCL, SOX2, PATZ1, LEO1, RING1B, UBTF, TFAP4, SIN3B, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, KLF1, SOX9, E2F6, TRIM24, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ZMYND8, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, ZNF76, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF384, ZNF35, NFYC, TAF15, CREBBP, SMAD4, ZNF518A, CBFA2T3, CDK8, SNRNP70, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, TCF7, YY2, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, RUVBL1, MYOD1, AR, KMT2D, ZNF324, HEXIM1, ZNF395, DMAP1, AHR, FOSL2, MBD3, ZNF391, HMG20A, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, SFMBT1, ZFHX2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, ZNF736, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, MLLT3, GATAD1, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, TCF25, ZNF639, ZNF285, ZNF750, JMJD6, FEZF1, HBP1, EHF, TFE3, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, ZNF45A, SMC1A, CBX1, MAFG, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, CDK6, NRF1, NR2C1, SUPT5H, CHD1, FOS, TGIF2, MED1, ZNF558, MYB, SCRT2, KDM6B, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, BRCA1, SP140, ZNF610, HIF1A, OTX2, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): PKNOX1,ADARB1,CFAP410,TRAPPC10,HSF2BP,SUMO3,RRP1B,ITGB2-AS1,PTTG1IP,UBE2G2,NDUFV3,TRPM2,TSPEAR,ITGB2,PFKL,COL18A1,FAM207A,WDR4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 33

Number of somatic mutations (non-coding): 27

Related genes and loops

Related gene: ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160207, ENSG00000160208, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000182871,

eachgene

Deatailed information for cohesin site CDBP00421113