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Basic information

CohesinDB ID: CDBP00421116

Locus: chr21-44809850-44811758

Data sourse: GSE67783, GSE86191, GSE98367, GSE116868, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, ENCSR703TNG, GSE25021, GSE38411

Cell type: MCF-7, RPE, Fibroblast, HCT-116, Monocytes, MB157, K-562, BCBL-1, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.889

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 52%, "5_TxWk": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ZNF621, NME2, XBP1, FOXA1, SUZ12, RBFOX2, LEO1, ZFHX2, HDGF, ATF3, ZNF444, KLF14, ZNF189, ZSCAN4, TP63, CDC5L, ELF1, BCLAF1, ZNF121, KLF10, ESR1, OCA2, ZIK1, CTCF, KLF1, E4F1, MNT, PAX8, DPF2, TRIM24, ZNF410, ZNF776, POU2F2, CHD8, MYCN, ZNF263, TOP2A, POU5F1, ZNF239, CTBP1, ZBTB1, ZBTB17, ZBTB48, STAT1, DDX5, NBN, ERG2, SP4, ZNF300, OGG1, MYC, RFX1, KLF12, GABPA, ZNF8, ZNF398, DNMT3B, HNRNPH1, ZNF639, NR3C1, SRSF3, KMT2A, CREB1, EZH2, KLF8, SPI1, HES1, IRF1, HDAC2, SSRP1, GATAD2B, ZNF785, SMARCA5, PTBP1, SALL2, RUNX1, SMC1A, HDAC1, CRY1, ZFX, TET2, ERG3, ZNF473, ZNF770, ZNF18, NSD2, ZBTB2, ZNF384, ZNF184, ZNF280C, NFIB, ARNT, CBFA2T3, PBX3, SUPT5H, SMARCB1, CHD1, GMEB1, ZNF3, KLF9, NCOA1, STAT5A, RBM22, SP1, BCL11A, PHF20, ARID2, ATF7, TCF3, AATF, SMC3, STAG1, MLLT1, TRP47, KLF13, FOXA2, ZNF207, MTA3, NFATC1, ZNF600, WT1, ZNF662, ZBTB33, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, ZNF148, NEUROD1, ZNF521, SP140, ZNF311, KLF15, TAL1, GATA1, AGO2, ZNF143, ZSCAN26, KLF4, ZNF592, NCOA3, ZNF544, KDM5B, PKNOX1, BCL6B, EGR2, AR, EGR1, HSF1, ZBTB26, MYNN, BRD4, NCOR1, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): NDUFV3,FAM207A,CFAP410,TRPM2,PKNOX1,COL18A1,ITGB2,ITGB2-AS1,SUMO3,PFKL,WDR4,TRAPPC10,ADARB1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 24

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000184900, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000182871,

eachgene

Deatailed information for cohesin site CDBP00421116