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Basic information

CohesinDB ID: CDBP00421118

Locus: chr21-44814747-44820942

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, GSE126634, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE93080, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR748MVX, ENCSR981FDC, GSE62063, GSE206145, ENCSR984DZW, ENCSR217ELF, GSE38395, GSE55407, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE131956, GSE129526, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, ENCSR000ECS, GSE38411

Cell type: RH4, GM10847, GM2610, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, HAP1, GM19099, Macrophage, MCF-7, GM12892, Ramos, THP-1, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 33% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.378

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "2_TssAFlnk": 21%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, ZBTB7B, HDGF, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, ZNF121, E2F5, LMO2, OCA2, MED26, HDAC8, ZNF561, SOX5, ZNF211, E2F4, DEK, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, TOP2A, CTBP1, ZMYND11, STAT1, SAP130, ERG, ZBTB8A, SMARCA4, RFX1, ZNF197, ZNF398, RCOR1, NR2F6, DACH1, CD74, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, ZNF785, DRAP1, NR2C2, HCFC1R1, RUNX1, HDAC1, CEBPA, NKX2-2, CRY1, IRF3, TET2, SP5, TRIM22, SMARCC1, PRDM10, TFDP1, ZBTB10, ELK1, SNIP1, FOXJ2, SP2, SMARCB1, ZNF584, PML, PIAS1, SMAD1, IKZF5, ARID2, RBM25, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, PAF1, SS18, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, TCF4, ZFP36, MAF1, PLAG1, KLF4, ZFP69B, BCL11B, ZKSCAN8, ZBTB6, MED, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, HNRNPK, ATF3, ZFP64, RUNX3, WDHD1, CBFB, DPF1, TP63, MITF, ZNF467, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, ZNF677, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZNF317, NONO, SRF, DDX5, ZNF329, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, ZNF560, TBL1XR1, KLF8, ARHGAP35, GRHL2, EBF3, ZBTB14, SSRP1, SMARCA5, NFIL3, THAP11, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, BACH1, DAXX, NFIB, ZNF48, NFYA, PBX3, NCAPH2, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF441, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, TBX2, ZNF468, PGR, PATZ1, LEO1, RING1B, UBTF, TFAP4, SIN3B, MXD4, ZNF189, SMARCE1, RLF, KLF6, NFE2L2, SAP30, ESR1, ZNF217, TP73, KLF1, SOX9, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, HIC1, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, PHF21A, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, ZNF343, DNMT3B, INO80, SRSF3, EZH2, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, NFYB, ZNF554, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF35, CREBBP, NFYC, TAF15, SMAD4, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, SREBF2, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, HDAC6, ZNF692, GTF2B, TCF7, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NEUROG2, NR2F1, KDM5B, TCF7L2, T, AR, ZNF445, HEXIM1, ZNF395, DMAP1, AHR, FOSL2, MBD3, ZNF391, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF90, NFIC, CTCFL, KLF14, MECOM, KLF5, TRIM28, BCLAF1, RCOR2, USF2, TCF12, EP300, BAF155, GATA6, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, ATRX, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, ZNF300, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, HBP1, TFE3, IRF1, SREBF1, ZGPAT, NAB2, ZNF766, MRTFB, ATF1, PTBP1, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, NMYC, TWIST1, NSD2, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, ZSCAN30, OSR2, ZNF184, GATA4, SMAD2, NRF1, NR2C1, CHD1, FOS, SUPT5H, MED1, KDM6B, CEBPD, MYB, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, NCOA4, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, CLOCK, MAZ, ZNF304, ZNF24

Target gene symbol (double-evidenced CRMs): WDR4,PFKL,TRPM2,COL18A1,CFAP410,ITGB2-AS1,PTTG1IP,SUMO3,PKNOX1,TRAPPC10,NDUFV3,FAM207A,ADARB1,ITGB2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 59

Number of somatic mutations (non-coding): 10

Related genes and loops

Related gene: ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000184900, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000182871,

eachgene

Deatailed information for cohesin site CDBP00421118