Deatailed information for cohesin site CDBP00421127

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  • Basic information
  • CohesinDB ID: CDBP00421127
  • Locus: chr21-44850330-44851998
  • Data sourse: GSE67783, GSE72082, GSE86191, GSE98367, GSE111913, GSE206145, ENCSR054FKH, ENCSR153HNT
  • Cell type: RPE, HCT-116, Hep-G2, RT-112, K-562, HSPC, Macrophage
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 2% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.922
  • Subunit: SA1,Rad21,SMC1
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 81% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "4_Tx": 61%, "5_TxWk": 20%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, PITX3, HDAC8, ZNF561, SOX5, PYGO2, E2F4, DEK, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, CTBP1, ZMYND11, DUX4, STAT1, SAP130, ERG, EZH1, SMARCA4, TOP1, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, EPAS1, GABPB1, ZHX2, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, DRAP1, MXI1, RELB, HCFC1R1, EP400, RUVBL2, RUNX1, CEBPA, HDAC1, NKX2-2, TET2, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZXDC, ATF2, SP2, SMARCB1, PML, SMAD1, NR1H2, EVI1, IKZF5, ARID2, ELL2, ETV4, NFATC3, CBFA2T2, CBX3, CREM, CHD2, PAF1, NFATC1, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, SPIB, PLAG1, KLF4, BCL11B, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, PBX2, SRSF4, ATF3, THRB, ZFP64, CBFB, TP63, ZNF467, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, JUN, CTCF, MNT, ZBTB20, DPF2, IRF4, ZNF423, RBPJ, TFAP2C, MLX, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, ZNF626, KDM4A, HOMEZ, RXRA, PRDM14, TEAD2, HNRNPH1, TERF2, MIER3, VDR, NR3C1, ESRRA, STAT5B, KMT2A, KLF8, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, SOX13, AFF4, POU4F2, ZNF18, SP3, ARNT, ZNF48, NFYA, PBX3, NCAPH2, HMGXB4, TEAD3, TAF7, KLF9, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, TP53, ZNF334, PHF5A, BRD2, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, CUX1, IRF9, TBX2, PGR, PATZ1, LEO1, UBTF, TFAP4, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, KLF1, ZNF714, SOX4, E2F6, TRIM24, RFX5, PRKDC, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, KLF12, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, INO80, EZH2, ZNF652, PHF8, ZNF436, SPI1, PCBP1, HDAC2, INTS13, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ZNF16, ERG3, MYBL2, RARA, ZNF35, NFYC, CREBBP, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, SUPT16H, NCOA1, GTF3C2, SREBF2, RBM22, NR4A1, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PTTG1, CXXC4, PPARG, TBL1X, GTF2B, ZNF30, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NEUROG2, TCF7L2, KDM5B, NR2F1, PKNOX1, T, AR, ZBTB16, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, HMGN3, SUZ12, RBFOX2, ZFHX2, NFIC, CTCFL, MECOM, CDX2, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, GATA6, CREB3, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ID3, HINFP, MLLT3, GATAD1, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF285, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, TWIST1, IRF2, PRPF4, RUNX2, GATA4, NRF1, NR2C1, FOS, CHD1, SUPT5H, TGIF2, MED1, KDM6B, MYB, CEBPD, SCRT2, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, GATA1, HAND2, CEBPG, SP7, NR2F2, ZNF687, NFKBIZ, BHLHE40, PTRF, TAF1, ZNF579, ZBTB40, MYNN, CLOCK, MAZ, MEF2D, ZNF24
  • Target gene symbol (double-evidenced CRMs): PFKL,PTTG1IP,CFAP410,FAM207A,ADARB1,TRPM2,TRAPPC10
  • Function elements
  • Human SNPs: HDL_cholesterol_levels_in_current_drinkers
  • Number of somatic mutations (coding): 188
  • Number of somatic mutations (non-coding): 49
  • Related genes and loops
  • Related gene: ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000183255, ENSG00000160256, ENSG00000197381,
  • Related loop: chr21:27500000-27525000~~chr21:44825000-44850000, chr21:44050000-44075000~~chr21:44850000-44875000, chr21:44075000-44100000~~chr21:44850000-44875000, chr21:44325000-44350000~~chr21:44850000-44875000, chr21:44799411-44802024~~chr21:44845318-44847256, chr21:44799651-44802591~~chr21:44845216-44847176, chr21:44799726-44802540~~chr21:44845295-44847056, chr21:44816840-44819191~~chr21:44845055-44847370, chr21:44817582-44819008~~chr21:44845213-44846787, chr21:44845305-44846867~~chr21:44873085-44874364, chr21:44845305-44846867~~chr21:44882190-44883389, chr21:44845323-44847405~~chr21:44871275-44872729, chr21:44845331-44847295~~chr21:44932164-44933556, chr21:44850000-44875000~~chr21:44950000-44975000, chr21:44850000-44875000~~chr21:45125000-45150000, chr21:44850000-44875000~~chr21:45325000-45350000, chr21:44850000-44875000~~chr21:46050000-46075000,
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