Deatailed information for cohesin site CDBP00421129

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  • Basic information
  • CohesinDB ID: CDBP00421129
  • Locus: chr21-44857206-44857817
  • Data sourse: GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE86191
  • Cell type: K-562, Fibroblast, HCT-116, RPE
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 1% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.956
  • Subunit: SA1,Rad21,SA2
  • CTCF binding site: non-CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 81% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "4_Tx": 69%, "5_TxWk": 24%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOXA1, HDGF, THAP1, PAX5, TEAD1, E2F5, LMO2, OCA2, HDAC8, E4F1, ARID5B, PYGO2, E2F4, ZNF410, GATAD2A, ZNF263, POU5F1, TOP2A, CTBP1, ZMYND11, STAT1, SAP130, ERG, SMARCA4, FOXK2, ZNF197, RCOR1, DACH1, NFRKB, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, GATA2, ZNF644, MXD3, FLI1, HCFC1, NR2C2, MXI1, RELB, HCFC1R1, EP400, RUNX1, HDAC1, CEBPA, TET2, PRDM10, ZBTB2, TFDP1, ELK1, ATF2, FOXM1, ZNF584, GMEB1, PML, PIAS1, SMAD1, EVI1, STAT5A, IKZF5, AFF1, MBD2, NFATC3, CBFA2T2, CBX3, CREM, PAF1, WT1, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, PLAG1, KLF4, BCL11B, ZKSCAN8, MED, EGR2, RBM14, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, XBP1, KDM4B, PBX2, ATF3, ZFP64, CBFB, TP63, MITF, JMJD1C, MAF, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, LMO1, DPF2, DDX20, TFAP2C, RBPJ, MTA2, ZBTB17, ZBTB48, NONO, NBN, PHB2, PBX1, HOMEZ, NKX3-1, PRDM14, LEF1, HNRNPH1, MIER3, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, GRHL2, SSRP1, ZSCAN29, SMARCA5, NFIL3, CC2D1A, LDB1, EZH2phosphoT487, ZNF770, ZMIZ1, ZNF18, ARNT, BACH1, ZNF48, ZEB2, NFYA, HMBOX1, ETV6, TEAD3, U2AF1, USF1, BCL11A, TFAP2A, ATF7, CTBP2, SMC3, STAT2, STAG1, MLLT1, TRP47, AGO1, MTA3, EBF1, MEIS1, ZNF580, ZKSCAN1, BCL3, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, PHF5A, KAT8, TBX21, EGR1, RB1, RNF2, JUND, BRD4, CUX1, IRF9, PGR, FANCL, CBX5, LEO1, UBTF, TFAP4, SIN3B, BMI1, ATF4, MXD4, SMARCE1, RLF, KLF6, NFE2L2, ESR1, KLF1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, TBP, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, PHF8, SPI1, PCBP1, HDAC2, NCOA2, ETV5, SIN3A, ERG3, MEF2A, CREBBP, ZNF384, RARA, TAF15, SMAD4, CBFA2T3, CDK8, NCOA1, RBM22, MAFK, NR4A1, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, TCF7, ZNF318, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, NEUROG2, KDM5B, PKNOX1, MYOD1, AR, ZBTB16, HEXIM1, ZNF395, AHR, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, ZNF90, ZNF274, NFIC, CTCFL, MECOM, HDAC3, TRIM28, ETV1, USF2, TCF12, EP300, BAF155, CREB3, SOX6, RAD51, E2F1, TEAD4, FOXA3, ZNF175, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, MIER1, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, HES1, SREBF1, ZIM3, ATF1, PTBP1, SMC1A, CBX1, FIP1L1, ZFX, SMAD3, NSD2, IRF2, BRD9, RUNX2, ZNF184, NRF1, NR2C1, SUPT5H, CHD1, FOS, MED1, CEBPD, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, ZBTB7A, CCNT2, TCF3, KLF13, FOXA2, RBBP5, E2F8, ZNF600, ZBED1, ZBTB33, ZNF589, YY1, ZNF148, SP140, HIF1A, BHLHE22, GATA1, CEBPG, NCOA3, NR2F2, ZNF83, BHLHE40, PTRF, TAF1, ZBTB40, MYNN, MAZ, MEF2D, ZNF24
  • Target gene symbol (double-evidenced CRMs): CFAP410,PFKL,ADARB1,PTTG1IP,TRAPPC10,FAM207A,TRPM2
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 24
  • Number of somatic mutations (non-coding): 6
  • Related genes and loops
  • Related gene: ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000183255, ENSG00000160256, ENSG00000197381,
  • Related loop: chr21:44050000-44075000~~chr21:44850000-44875000, chr21:44075000-44100000~~chr21:44850000-44875000, chr21:44325000-44350000~~chr21:44850000-44875000, chr21:44850000-44875000~~chr21:44950000-44975000, chr21:44850000-44875000~~chr21:45125000-45150000, chr21:44850000-44875000~~chr21:45325000-45350000, chr21:44850000-44875000~~chr21:46050000-46075000,
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